摘要
目的:探讨注射用红花黄色素联合胺碘酮对老年冠心病室性期前收缩患者血清凝血酶敏感蛋白-1(TSP-1)、超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)的影响及临床治疗效果。方法:将120例老年冠心病室性期前收缩患者按照入院先后顺序分为治疗组、对照组各60例,对照组予以常规药物治疗,治疗组在常规用药基础上加用注射用红花黄色素,1个月为1个疗程,观察治疗前后血清TSP-1、hs-CRP、IL-6的表达,24h Holter检测室性期前收缩前后变化。结果:治疗组室性期前收缩控制率为93%,优于对照组的85%;临床症状均明显改善,治疗组高于照组显;血清TSP-1、hsCRP、IL-6的降低幅度,治疗组明显高于对照组。结论:注射用红花黄色素具有明显改善老年冠心病室性期前收缩患者临床症状,减少室性期前收缩次数,降低血清TSP-1、hs-CRP、IL-6水平的作用。
Objective： To investigate the impact and clinical outcomes of Safflower yellow injection joint amiodarone on thrombospondin -1 （TSP-1）, high-sensitivity C-reactive protein （ hs-CRP ）, interleukin -6 （ IL-6 ） of senile coronary heart disease in patients with ventricular premature beat.Methods：120 cases of senile coronary heart disease patients with premature ventricular beats according to admission order were divided into control group and treatment group of 60 peo- ple.The control group was given routine drug treatment , while the treatment group used injection of safflower yellow pig- ment on the basis of conventional drugs.The expression of TSP - 1, hs - CRP, and IL - 6 in serum were detected before and after treatment ventricular beats.R with Enzyme-linked immunoassay and 24 hour Hoher detected the changes before and after premature esults： The ventricular premature beat of the study group is better than the control group（ 93%VS.85% ）;Clinical symptoms were significantly improved, the level of the study group is significantly higher than the control group; compared with the control group, the reduction of Serum TSP-I, hs-CRP, IL-6 is significantly higher in the study group. Conclusion：The safflower yellow for injection plays an important role in significantly improving clinical symptoms in el- derly patients with coronary heart disease ventricular premature beat., reducing the number of ventricular premature beat. and reducing the level of serum TSP- 1, hs-CRP, IL-6.
出处
《中医药临床杂志》
2015年第5期663-665,共3页
Clinical Journal of Traditional Chinese Medicine
基金
国家中医药管理局重点专科建设项目
