急性心力衰竭患者血浆BNP水平检测及其临床意义探讨

Investigation of plasma BNP level detection and its clinical significance in acute heart failure patients

目的探讨急性心力衰竭患者血浆B型尿钠肽(BNP)水平检查与临床意义。方法 80例急性心力衰竭患者作为观察组,选取同期体检中心80例健康自愿者作为对照组,比较两组血浆BNP、左室射血分数(LVEF)及肺动脉压(PAP),将观察组患者按照纽约心脏病协会(NYHA)分级分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级,比较不同分级患者血浆BNP水平。结果观察组血浆BNP值明显高于对照组,LVEF和PAP水平明显低于对照组,比较差异有统计学意义(P<0.05);观察组患者随着心功能分级越高血浆BNP水平越高,组间各值比较,差异有统计学意义(P<0.05)。结论急性心力衰竭患者血浆BNP水平随着心力衰竭程度加重而升高,临床中通过检测患者血浆BNP值判定患者心力衰竭程度。

Objective To investigate plasma B-type natriuretic peptide （BNP） level detection and its clinical significance in acute heart failure patients. Methods A total of 80 acute heart failure patients were divided into observation group, and another 80 healthy volunteers at the same period were in control group. Comparisons were made on plasma BNP, left ventrieular ejection fraction （LVEF）, and pulmonary artery pressure （PAP）. Classification was made by New York heart association （NYHA） criterion into I, II, Ill, and 1V grades. Plasma BNP levels in each grades were compared. Results The observation group had much higher plasma BNP level and lower LVEF and PAP levels than the control group, and their differences had statistical significance （P〈O.05）. The observation group had high plasma BNP level along with the increasing of cardiac function classification, and the differences across each grades （P〈O.05）. Conclusion Acute heart failure patients have high plasma BNP level along with the increasing of heart failure degree. Detection of plasma BNP level can be applied for heart failure judgment in clinic.