原发性高血压血清胆红素水平与左室舒张功能的相关性研究

The Correlation Study of Serum Bilirubin Level and Left Ventricular Diastolic Function For the Patients with Primary Hypertension

目的:探讨原发性高血压(EH)患者血清胆红素水平与左室舒张功能的相关性及临床意义。方法:选取临床确诊的EH患者112例,其中伴左心室舒张功能不全者(LVDD)62例作为A组,无LVDD者50例作为B组,另选取健康者45例作为对照组,监测3组患者血清总胆红素(TBIL)、直接胆红素(DBIL)及间接胆红素(IBII)的水平,测定左心室舒张功能指标,并比较分析血清胆红素水平与左室舒张功能的相关性。结果:A组患者的左房内径(LA)(34.87±3.34)mm、右室内径(LV)(48.45±3.56)mm显著高于对照组的LA(30.76±3.45)mm、LV(45.01±4.11)mm,差异具有统计学意义(P<0.05),B组与对照组在LA和LV上比较不具有统计学意义(P>0.05);A组患者舒张期早期最大血流速度(E峰)、舒张晚期最大血流速度(A峰)、E/A及与B组和对照组比较存在显著差异,差异具有统计学意义(P<0.05);A组患者TBIL水平(10.14±3.79)mmol/L、IBIL水平(3.72±2.13)mmol/L显著高于B组患者TBIL水平(12.23±4.42)mmol/L、IBIL水平(3.46±1.93)mmol/L和对照组患者TBIL水平(15.10±4.24)mmol/L、IBIL水平(3.31±2.02)mmol/L,差异具有统计学意义(P<0.05);A组患者DBIL水平高于其他两组,差异不显著,无统计学意义(P>0.05)。相关性分析结果为,胆红素与E值及E/A比值呈正相关(γ分别为0.603和0.531,P<0.05)。结论:原发性高血压患者TBIL及IBIL水平与LVDD具有相关性,血清胆红素水平检测在心脏左心室舒张功能不全的诊断具有重要临床意义。

Objective：To investigate the correlation and clinical significance of the serum bilirubin levels and left ventricular diastolic function in patients with essentialhypertension （EH）. Methods：Selected 112 patients with essentialhypertension （EH） ,62 cases with left ventricular diastolic dysfunction （LVDD） as research group, 50 cases without the LVDD as control group, and the other 45 cases as the health blank group. Serum total bilirubin （TBIL）, direct bilirubin （DBIL） and indirect bilirubin （IBII） level in three groups were detected and determined the left ventricular diastolic function index. And then the correlative analysis was carried out between serum biliru- bin level and left ventricular diastolic function. Results： The E, A, E / A, and LVEF of the trial group , the blank group and control group are relatively difference, respectively; patients TBIL and IBIL level with the other two groups, both showed a significant difference （P 〈 0.05）, while DBIL level was higher then the other two groups, but the difference was not significant （ P 〉 0.05 ） ; correlation analysis showed that the bilirubin value of E and E/ A ratio were positively correlated（r =0.603 and 0.531 ,P 〈0.05）. Conclusions：TBIL and IBIL level show correlation with LVDD in patients with primary hypertension. The serum bilirubin level has important clinical significance in the diagnosis of left ventricular diastolic dysfunction.