芬兰某市青春期女童血清C-反应蛋白体脂总量变化趋势及相关性

Growth pattern and correlation of C-reactive protein and total fat mass in girls during pubertal growth

目的观察青春期前（即生长突增前期）至成年早期女童体内血清C-反应蛋白水平和体脂总量的变化情况,探讨两者是否具有循轨特征及两者之间的关系。方法对396名芬兰于韦斯屈莱市及周边的9-13岁健康女孩进行为期7 a追踪研究。采用酶联免疫吸附法检测女孩血清C-反应蛋白水平,采用双能X-线吸收仪检测其体脂含量。利用MLwin软件分别对女孩体内C-反应蛋白水平和体脂总量的总体变化趋势进行拟合。结果青春期女孩体内血清C-反应蛋白水平和体脂总量均随年龄增长呈上升趋势（C-反应蛋白水平随年龄增长依次为5.2,5.3,5.5,6.1 ng/m L,体脂总量随年龄增长依次为10.1,13.7,15.4,19.4 kg）,且具有循轨特征,二者之间存在正相关（R^2=0.210,P〈0.01）。结论在儿童期体脂含量较高的人,其成年后患代谢性相关疾病的风险可能较高。

Objective To investigate changes of serum C-reactive protein （CRP） and whole body fat mass （FM） in girls during the transition from pre-puberty to early adulthood. Methods A 7-year follow-up study of 396 healthy Finnish girls aged 11.2 years at the baseline. Serum concentration of CRP was assessed by using enzyme-linked immunosorbent assay. Body FM was measured with dual-energy X ray densitometry（DXA）. Results CRP and FM increased with age from pre-puberty to early adulthood, the increasement of CPR was 5.2, 5.3, 5.5 and 6.1 ng/mL; of FM was 10.1, 13.7, 15.4 and 19.4 kg respectively, and both CRP and FM correlated with each other（R^2 =0.210, P〈0.01 ）. Conclusion Individual who has higher body fat percentage during childhood might have higher risk of metabolic disorders in adulthood.