早期强化降压治疗对急性脑出血患者血清高迁移率蛋白-1及C反应蛋白水平的影响

The impact analysis of early intensive antihypertensive treatment to expression of high mobility rate protein-1 and C-reactive protein in patients with acute cerebral hemorrhage

目的研究早期强化降压治疗对急性脑出血的患者血清高迁移率蛋白-1及C-反应蛋白水平的影响。方法选取2012年1月至2014年1月接诊的100例急性脑出血患者作为研究对象,按入院顺序将其分为对照组(2012年1月至2013年1月)和观察组(2013年2月至2014年1月),各50例。对照组给予常规治疗,观察组在对照组基础上给予早期强化降压治疗。观察分析两组患者治疗前后血清高迁移率蛋白-1(HMGB-1)及C-反应蛋白(CRP)水平、神经功能缺损程度评分(NDS),并评定两组患者的治疗总有效率。结果两组患者治疗前的血清HMGB-1水平、CRP水平以及NDS评分差异无统计学意义(P>0.05);在治疗后两组患者的这三项指标均有所下降,且观察组下降的幅度更为明显,差异具有统计学意义(P<0.05)。对照组治疗总有效率为66.00%,而观察组为90.00%,观察组的治疗总有效率明显高于对照组,差异具有统计学意义(P<0.05)。结论早期强化降压治疗可以有效降低急性脑出血患者血清HMGB-1水平及CRP水平,治疗急性脑出血的临床效果良好。

Objective To study the impact of early intensive antihypertensive treatment to expression of high mobility rate protein -1 and C- reactive protein in patients with acute cerebral hemorrhage. Methods 100 patients with acute cerebral hemorrhage in our hospital from Janu-ary 2012 to January 2014 were studied,and they were divided into the control group（ January 2012 to January 2013 ）and the observation group （ February 2013 to January 2014）according to the order of their admission,50 cases each. The control group received conventional treatment,and the observation group received early intensive antihypertensive treatment on the basis of the control group. To analyze serum high mobility protein-1（HMGB-1）and C- reactive protein（CRP）levels,the degree of neurological deficit score（NDS）before and after treatment of the two groups of patients,and assess the total treatment efficiency of the two groups. Results Serum HMGB-1 levels,CRP levels and NDS score of the two groups did not have significant difference before treatment,without statistically significant（ P 〉0. 05）. The three indicators in two groups of patients after treatment declined. And the decrease of the observation group is more obvious. The comparison of two groups was statistically signifi-cant（ P 〈0. 05）. The total treatment effective rate of the control group was 66. 00%,and the observation group was 90. 00%. The total treat-ment efficiency of the observation group was significantly higher,and the difference was significant,with statistical significance（ P 〈0. 05）. Conclusion Early intensive antihypertensive therapy can reduce acute cerebral hemorrhage serum HMGB-1 levels and CRP levels,and treat a-cute cerebral hemorrhage well.