餐后有氧运动对初治肥胖的2型糖尿病患者糖脂代谢及胰岛素抵抗和瘦素的影响

The influence to glucose and lipid metabolism and insulin resistance and leptin of postprandial aerobic exercise in newly diagnosed obese type 2 diabetes

目的探讨餐后有氧运动对初治肥胖的2型糖尿病患者糖脂代谢及胰岛素抵抗和瘦素的影响。方法选取2013年1月至2014年1月初步确诊的2型糖尿病患者100例,采用随机数字表法随机分为研究组和对照组,每组患者各50例。研究组患者餐后进行有氧运动,对照组患者服用药物进行治疗。观察比较两组患者的糖脂代谢、胰岛素抵抗和瘦素等指标的变化情况。结果两组患者经治疗后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb Alc)和胰岛素抵抗指数(IR)均显著低于治疗前(均P<0.05),研究组FPG、2 h PG、Hb Alc和IR等指标改变较对照组更明显(均P<0.05)。两组患者经治疗后TG、TC和瘦素水平均显著低于治疗前(均P<0.05),研究组TG、TC和瘦素水平较对照组改善更明显(均P<0.05)。结论餐后有氧运动可显著改善初治肥胖的2型糖尿病患者的糖脂代谢能力,降低胰岛素抵抗和瘦素水平,降低体质指数,效果较好。

Objective To investigate the influence to glucose and lipid metabolism and insulin resistance and leptin of postprandial aero-bic exercise in newly diagnosed obese type 2 diabetes. Methods 100 cases with initial diagnosis of type 2 diabetes were selected from our hospital during the period from January 2013 to January 2014,they were randomly divided into two groups according to random number table：the study group and the control group,50 cases in each group. The patients of the study group were treated in postprandial aerobic exercise. The patients of the control group were treated with drugs,glucose and lipid metabolism,insulin resistance and leptin of two groups were compared. Results FPG,2 hPG,HbA1c and IR after treatment of two groups were significantly lower than before treatment（all P 〈0. 05）. FPG,2 hPG,HbA1c and IR index change of the study group were more obvious than in the control group（all P 〈0. 05）. TG,TC and leptin levels after treatment of two groups were significantly lower than before treatment（all P 〈0. 05）. TG,TC and leptin levels of the study group were more significant im-provement than the control group（all P 〈0. 05）. Conclusion Postprandial aerobic exercise can significantly improve the glucose and lipid me-tabolism of initial treatment of obesity type 2 diabetes,can reduce insulin resistance and leptin levels,can lower the body mass index,and had the better efficacy.