创伤后应激障碍神经生物学机制研究进展

Research advances of biological mechanisms underlying post-traumatic stress disorder

背景已知多种因素可引起创伤后应激障碍（post-traumatic stress disorder，PTSD），然而其发生的神经生物学机制尚不明确。目的综述目前PTSD神经生物学机制的研究进展。内容从动物模型和恐惧记忆形成的不同阶段出发，阐述PTSD的神经生物学机制。趋向PTSD形成涉及多种神经生物学改变，然而这些改变如何引起PTSD尚需进一步研究。

Background A variety of factors can lead to post-traumatic stress disorder （FFSD）, however the underlying neurobiological mechanisms remain unclear. Objective To review the research advances of neurobiological mechanisms of PTSD. Content This paper elucidated the neurobiological mechanisms of PTSD based on animal models and different stages of fear memory formation. Trend A variety of neurobiological changes contribute to the pathogenesis of PTSD, however, how these changes lead to PTSD needs to be further studied.