clock基因rs3817444多态性与大学生抑郁症、原发性失眠的关联分析

Association of Clock Gene rs3817444 Polymorphism with Depressions and Primary Insomnia

目的:探讨clock基因与大学生抑郁症、原发性失眠的关联。方法:用Snapshot SNP分型技术对88例(其中抑郁睡眠障碍65例)大学生抑郁症患者、55例原发性失眠患者和110名大学生正常对照进行clock基因rs3817444位点分型,比较三组间该基因多态性基因型和等位基因频率的差异。结果:与对照组相比,抑郁症组rs3817444多态性的基因型和等位基因的频率差异无统计学意义(P>0.05);与对照组相比,原发性失眠组rs3817444多态性的等位基因频率差异有统计学意义(P<0.05);对rs3817444多态性三种基因型C/C、A/C、A/A抑郁症和原发性失眠大学生的临床资料比较,显示各项没有明显差异(P>0.05)。结论:clock基因rs3817444多态性可能与大学生抑郁症的发病无关联,但与大学生原发性失眠可能关联。

Objective：To explore the association of clock gene with depressions and Primary insomnia.Methods：Theclock gene rs3817444 was genotyped by Snapshot SNP technique in 88 depressions（includng 65 depressions with insomin-ia）,55 Primary insomnia and 110 controls.Results：No significant differences for genotype and allete gene in clock geners3817444 were observed between depressions and healthy controls（P〉0.05）,while significant differences for allete gene inclock gene rs3817444 were presented between Primary insomnia and healthy controls（P〈0.05）;Comparing the depressionand the Primary insomnia＇s clinical data between three genotypes of the rs3817444 polymorphism C/C、A/C、A/A,itshowed no significant differences（P〉0.05）.Conclusion：The clock gene rs3817444 polymorphism may relate to Primary in-somnia,but not depressions.