血清25羟维生素D与缺血性心脑血管病相关性荟萃分析

Relationship between 25 hydroxy-vitamin D and cerebrovascular disease & stroke: A systemic review

目的系统评价血清25羟维生素D水平与缺血性心脑血管病的相关性。方法运用Cochrane系统评价方法,检索美国Pub Med、维普数据库VIP、万方数据库及中国学术期刊全文数据库(CNKI),筛选血清25羟维生素D水平与缺血性心脑血管病事件发生率的试验,并用CMA2软件进行统计分析。结果共初检出76篇文献,经筛选最终纳入20项试验进行分析,共85 248例患者。Meta分析结果显示,低浓度血清25羟维生素D组的缺血性心脑血管病事件发生率明显高于高浓度组(合并RR=1.308,Z=5.438,P<0.01)。结论本系统评价结果显示,缺血性心脑血管病风险可能与低浓度血清25羟维生素D水平相关。但由于本系统评价纳入的随机对照试验数目不多,有必要开展更多设计严谨,大样本、多中心的前瞻性试验来确证这种趋势。

Objective To evaluate the correlation between vitamin D and ischemic cardiocerebrovascular disease. Methods We searched Pubmed,VIP,Wan Fang and CNKI database. The data were analyzed by CMA2 software. Results Twenty-one studies met the inclusion criteria. In total,data from 85 248 patients were performed by meta analysis. The ischemia cardio-cerebrovascular diseases event in low concentration vitamin D group was higher than that in high concentration group,and the difference was significant（ Pooled RR = 1. 308,Z = 5. 438,P〈0. 01）. Conclusions The risk of ischemic cardiocerebrovascular disease are correlative with the low concentration Vitamin D. However the above conclusion are made from the limited evidence. So,multi-center large-scale prospective trials of higher quality are needed to confirm the conclusion.