青年和老年乳腺癌分子分型对比

A Comparison on Molecular Subtypes of Breast Cancer between the Youth and Elderly

目的比较青年和老年乳腺癌分子分型的差异。方法选取贵阳医学院附属医院乳腺外科收治的青年乳腺癌患者61例(青年组)及老年乳腺癌患者58例(老年组),采用免疫组化Envision法检测2组患者的雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER-2)、Ki-67的表达,并根据免疫组化结果,将乳腺癌分为4种分子亚型,即Luminal A型、Luminal B型、HER-2过表达型、三阴性型,分析其分布情况。结果老年组患者乳腺癌分子分型以Luminal A型为主(46.6%),Luminal B型次之,占37.9%,HER-2过表达型及三阴性型分别占8.6%和6.9%,青年组患者以Luminal B型为主(39.3%),Luminal A型次之,占23.0%,HER-2过表达型及三阴性型分别占18.0%和19.7%。老年组患者Luminal A型乳腺癌所占比例高于青年组患者,差异有统计学意义(P<0.05)。结论老年乳腺癌分子分型以预后较好的Luminal A型为主,青年乳腺癌较老年乳腺癌更易出现HER-2过表达型及三阴性型,青年乳腺癌较老年乳腺癌肿瘤性质更恶劣。

Objective To compare molecular subtypes of breast cancer in the youth and elderly.Method 61 cases of youth patients（youth group）and 58 cases of elderly patients（elderly group）with breast cancer received in the department of Breast Surgery of the Affiliated Hospital of Guiyang Medical College were detected estrogen receptor（ER）,human epidermal growth factor receptor（HER-2）,progesterone receptor（PR）and Ki-67 expression with the method of Immunohistochemical Envision to classify breast cancer into four subtypes,namely Luminal A type,Luminal B type,HER-2over-expression type and triple-negative type,and analyze their distribution.Results In the elderly group,Luminal A type,Luminal B type,HER-2over-expression type and triple-negative type were respectively 46.6%,37.9%,8.6% and 6.9%,while in the youth were 23.0%,39.3%,18.0% and 19.7%.Elderly patients had higher incidence of Luminal A type than the youth patients and the difference was statistically significant（P〈0.05）.Conclusions The breast cancer molecular in elderly patients is mainly Luminal A type with a better prognosis,youth patients are more vulnerable to have HER-2over-expression and triple-negative types and breast cancer of the youth is much worse than that of the elderly.