微波辅助煅烧合成双相磷酸钙纳米颗粒

Microwave Assisted-Sintering Synthesis of Biodegradable and Cytocompatible Biphasic Calcium Phosphate Nanoparticles

采用微波辅助反应联用煅烧法制备纳米级的双相磷酸钙(BCP)颗粒,讨论了微波辅助过程中样品的组成变化,对不同温度煅烧制备的BCP样品进行了表征,并对其细胞相容性和生物降解性进行了评价.结果表明,通过本途径能将BCP纳米颗粒的制备过程缩短至8h,通过改变煅烧温度条件能有效调节BCP纳米颗粒的成分组成;3种HA百分含量分别为100%,89.9%和57.9%的BCP纳米颗粒均具有较好的细胞相容性和生物降解性.

Nanopowders of biphasic calcium phosphate（BCP）composites were prepared using microwave assistedsintering synthesis route.The phase transformation of the microwave irradiation was investigated.The chemical and phase composition,morphology and particle size of the samples were characterized.Cytocompatibility and biodegradability were also evaluated.Results show that the microwave irradiation shortened the formation time of the BCP to less than 8h.The variation of relative index ratio（RIR）differs at different sintering temperatures,three kinds of BCP nano-particles consisted different hydroxyapatite ratio,100%,89.9% and 57.9% was synthesized.All above mentioned BCP nanoparticles are found to be biocompatible and in vitro dissolvable.