帕那珠利的合成、精制及纯度研究

Synthesis,Refining and Purity Study of Ponazuril

为制备帕那珠利色谱纯品,以托曲珠利为原料合成了帕那珠利粗品,用冰乙酸、丙酮和乙醇为溶剂四次重结晶制得帕那珠利精制品,研究首次采用HPLC(紫外和蒸发光检测器)、DSC(示差扫描热分析)和凯氏定氮测定法检验纯度,并用制备型HPLC制得帕那珠利的色谱纯品。经检验帕那珠利精制品纯度为98.3%,帕那珠利色谱纯品DSC为单一峰,获得了较好的结果。

This paper established a method for obtaining the chromatographic purity ponazuril product.The coarse product of ponazuril was synthesized by tohrazuril＇ s crude material and then got purified product of ponazuril by recrystallizing it four times with ice acetic acid, acetone and ethanol as solvent. HPLC （UVD and ELSD）, DSC and Kjeldahl method were used to test the purity of the above refined product, Then obtained the pure ponazuril product with prep-HPLC. The purity of refined ponazuril product was 98.3%, The pure ponazuril product by prep -HPLC was an only one signal in DSC chart and The result was good.