丹地化瘀汤对哮喘急性发作患儿肺功能及Th1/Th2细胞功能调节作用的影响

Impact of acute asthma attack and Th1/Th2 cell function regulation of Dundee Huayu decoction on children with lung function

目的探讨丹地化瘀汤对哮喘急性发作患儿肺功能及Th1/Th2细胞功能调节作用的影响。方法 2013年1月至2014年1月选取在本院收治的120例哮喘急性发作期患儿为研究对象,根据随机数字表将患儿分为观察组及对照组各60例,对照组给予舒利迭雾化吸入治疗,50 mg/250 mg,2次·d-1,观察组在对照组基础上给予自拟地化瘀汤口服治疗,2组均持续治疗2周。对比分析2组患儿治疗效果及治疗前后肺功能及免疫功能的变化。结果观察组总有效率为96.67%,对照组总有效率为76.67%,差异有统计学意义(P<0.05)。观察组患儿治疗后第1 s呼吸气体的容积(FEV1)、用力呼吸的肺活量(FVC)及FVC占预计值百分比(FVC%)改善优于对照组(P<0.05)。观察组治疗后白细胞介素4(IL-4)、免疫球蛋白(Ig E)、干扰素(IFN-γ)和IL-4/INF-γ则显著低于对照组(P<0.05)。结论丹地化瘀汤能有效改善哮喘急性发作期患儿肺功能及免疫功能,提高哮喘患儿治疗效果。

Objective To explore the impact of acute asthma attack and Thl/Th2 cell function regulation of Dundee Huayu decoction on lung fimction in children. Methods Totally 120 cases of children with lung function were divided into an observation group （n = 60） and a control group （n = 60） from January, 2013 to January, 2014. The control group were treated with seretide inhalation therapy, 50 mg/250 mg, twice a day. The observation group were received with Dundee Huayu decoction and seretide inhalation therapy. The courses of treatment were 2 weeks in both groups. The lung function and immune function before and after the treatment were compared between 2 groups. Results The total effective rate was 96.67% in the observation group and 76.67% in the control group （P 〈 0.05）. The first volume of breathing gas 1 s children after the treatment （FEV1）, forced expiratory vital capacity （FVC） and percent predicted FVC （FVC%） improved significantly in the observation group than those of the control group （P 〈 0.05）. The serum concen- trations of interleukin 4 （IL-4）, interferon （IFN-γ） and IL-4/INF-γ and immunoglobulin （IgE） in the observation group were lower than those of the control group （P 〈 0.05）. Conclusion Dundee decoction can effectively improve lung function and immune function in children with acute exacerbation of asthma.