尿微量白蛋白与血清胱抑素C联合检测对高血压早期肾损害诊断的应用价值

Application value of combined detection of urine albumin and serum cystatin in diagnosing early renal damage of hypertension

目的研究联合检测尿微量白蛋白(Um Alb)和血清胱抑素C(SCys-C)对高血压早期肾损害的诊断价值。方法选取高血压早期肾病患者80例为观察组,选取同期来院行健康体检者80例为对照组,统计分析2组患者SCys-C、肌酐和晨Um Alb的水平。结果观察组SCys-C、Um Alb均显著高于对照组(P<0.05),2组血肌酐水平比较差异无统计学意义(P>0.05)。相关性分析提示SCys-C与Um Alb呈现高度相关性(r=0.512,P<0.05),提示SCys-C的水平将随着Um Alb升高而升高。结论高血压早期肾损害患者损害程度较轻,血清肌酐水平尚未发生显著变化时,联合检测SCys-C及Um Alb对于诊断高血压早期肾病具有重要诊断价值。

Objective To study the diagnostic value on the combined detection of urine micro albumin（ Um Alb）and serum cystatin C（ Cys-C） value in the diagnosis of early renal damage in essential hypertension. Methods 80 cases of hypertension with early nephropathy were selected as the observation group,80 cases of people for healthy physical examination from the hospital in the same period were selected as the control group. The serum cystatin C,creatinine and morning urine albumin level of 2 groups were analyzed statistically. Results The serum Cys-C and urinary Um Alb levels in the observation group were significantly higher than those in control group（ P〈0. 05）. The difference of serum creatinine in the 2 groups was not statistically significant（ P〉0. 05）. The correlation analysis indicated that SCys- C and Um Alb appearred high correlation（ r = 0. 512,P〈0. 05）. It was suggested that SCys-C level would increase with the increase of Um Alb. Conclusion The degree of renal damage is mild in early hypertensive patients,so the serum creatinine level has not changed significantly. The combined detection of serum Cys-C and urine Um Alb has important value in the diagnosis of early hypertensive nephropathy.