祛痰利湿活血祛瘀类中药对糖尿病合并冠心病患者的实效性评价

Chinese medicine of expectorant dampness and wet activating blood and remove stasis treatment of patients with diabetic heart disease

目的观察并探讨祛痰利湿活血祛瘀类中药对糖尿病合并冠心病(DHD)患者的有效性。方法选择DHD患者96例,按照随机分组法分治疗组和对照组,各48例,治疗组在常规西医治疗的基础上加用祛痰利湿活血祛瘀类中药治疗,对照组仅予常规西医治疗。治疗前后监测2组空腹血糖(FBG)、餐后2 h血糖(2h PBG)、糖化血红蛋白(Hb Alc)水平,心电图变化,并在治疗后对中医证候总疗效进行评价。结果治疗后治疗组FBG、2h PBG和Hb Alc分别为(7.2±0.1)mmol/L、(8.9±0.2)mmol/L和(6.2±1.7)mmol/L,对照组为(7.5±0.2)mmol/L、(9.3±0.2)L)mmol/L和(7.2±1.4)mmol/L,2组相比差异具有统计学意义(P<0.05);治疗后治疗组心电图好转率93.8%(45/48),对照组为75.0%(36/48),2组相比差异具有统计学意义(P<0.05);治疗组中医证候总有效率为91.7%(44/48),对照组为72.9%(35/48),差异具有统计学意义(P<0.05)。结论祛痰利湿活血祛瘀类中药能明显降低DHD患者的血糖水平,改善心功能。

Objective To observe and explore the clinical value of expectorant dampness and wet activating blood and re- move stasis traditional Chinese medicine for patients with diabetic heart disease （DHD）. Methods The 96 patients with DHD were randomized divided into two groups, 48 cases in the treatment group and 48 cases in the control group. Observa- tion group were treated with expectorant dampness and wet activating blood and remove stasis traditional Chinese medicine on the basis of conventional Western medicine treatment, while the control group were treated with conventional Western medicine. Fasting glucose monitoring （FBG）,2h postprandial glucose （2h PBG）, glycosylated hemoglobin （HbAlc） levels, ECG changes of the two groups before and after treatment were monitored, and total effective of TCM syndrome were evaluat- ed after treatment. Results The difference of FBG,2h PBG, and HbAlc before treatment between the two groups was not statistically significant （ P 〈 0.05）, after treatment FBG, 2h PBG and HbAlc in the treatment group were （7.2 ± 0. 1 ） mmol/L, （8.9± 0.2） mmol/L and （6.2 ± 1.7） mmol/L, and were （7.5 ± 0.2） mmol/L, （9.3 ± 0.2） mmol/L and （7.2±1.4） mmol/L in the control group; after treatment, ECG improvement rate was 93.8% （45/48） in the treatment group,and ECG improvement rate was 75.0% （36/48） in the control group, the difference was statistically significant（ P 〈 0.05） ; total effective of TCM syndromes in treatment group was 91.7 % （44/48）, and was 72.9 % （35/48） in the control group, the difference was statistically significant （ P 〈 0.05）. Conclusion Expectorant dampness and wet activating blood and remove stasis traditional Chinese medicine can significantly lower blood sugar levels in patients with DHD, improve heart function.