阿霉素诱导心源性水肿动物模型的建立及相关防治药物的研究进展

Adriamycin induced cardiac edema establishment of animal model and prevention drug

阿霉素是一种有效的抗癌药物,但具有一定心脏毒性,因此可以使用阿霉素诱导建立心源性水肿动物模型。选用的实验动物主要为大鼠,造模方法为腹腔注射和尾静脉注射。阿霉素诱导心源性水肿的机制主要与氧化应激作用、钙含量过负荷、细胞凋亡、线粒体损伤等有关。根据其作用机制,防治药物在自由基清除剂、钙拮抗剂、细胞凋亡抑制剂、线粒体保护剂等方面的应用取得较大进展,为治疗心源性水肿提供了科学依据。

Adriamycin is a potent anti-cancer drugs, but with certain cardiac toxicity, and therefore can he used to establish doxorubicin-induced cardiac edema animal model. Selection of experimental animals mainly were rats, building method for abdominal cavity and tail intravenous injection. The mechanism of adriamycin induced cardiac edema mainly and oxidative stress, calcium overload and cell apoptosis, mitochondrial damage and so on. According to their mechanism of action of drugs in the prevention of free radical scavengers, calcium antagonists, inhibitors of apoptosis, mitochondrial protective agents has great progress, provide a scientific basis for the treatment of cardiac edema.