摘要
目的:探讨美托洛尔与辛伐他汀对冠心病患者(CHD)心率变异性(HRV)及其血脂、血浆同型半胱氨酸(Hcy)的不同影响。方法:选取2009年8月-2012年6月于笔者所在医院经冠状动脉造影术确诊的80例CHD患者作为研究对象,按入组顺序随机将其分为辛伐他汀组和美托洛尔组,每组40例。两组患者除给予常规相同的治疗药物外,辛伐他汀组给予辛伐他汀治疗,美托洛尔组给予美托洛尔治疗,治疗持续8周。观察比较两组患者治疗前后血压、24 h动态心电图、血脂和血浆同型半胱氨酸的变化。结果:两组患者治疗后的血压、心率均有明显下降,HRV时域指标SDNN、HRVTI和频域指标TP、LF、HF、LF/HF及血脂和Hcy水平均呈现不同程度的改善(P<0.05),而美托洛尔对HRV频域指标和Hcy水平的影响更为显著(P<0.05)。结论:美托洛尔和辛伐他汀均可改善CHD患者的血压、心率、HRV和Hcy水平,但美托洛尔在改善HRV频域指标和Hcy水平上有着更良好的作用。
Objective： To investigate the different effects of Metoprolol and Simvastatin on the heart rate variability（HRV）, blood lipid and homocysteine（Hcy） of patients with coronary heart disease（CHD）.Method： A total of 80 patients who were diagnosed as CHD according to the results of coronary angiography in our hospital from August 2009 to June 2012 were selected as research objects.All patients were randomly divided into the Simvastatin group and the Metoprolol group according to the group order, 40 cases in each group.Patients of two groups received the same conventional drug therapy, on the basis of drug therapy, the Simvastatin group was treated with Simvastatin, the Metoprolol group was treated with Metoprolol, the treatment lasted for 8 weeks.The changes of blood pressure, 24 h dynamic electrocardiogram, blood lipid and homocysteine between the two groups before and after treatment were observed and compared. Result： The blood pressures and heart rate all decreased obviously in the two groups after treatment, the indicators of SDNN, HRVTI, TP, LF, HF, LF/HF, blood liquid and Hcy were all improved when treated with Simvastatin or Metoprolol respectively（P〈0.05）.However, compared with the Simvastatin group, the changes of HRV frequency-domain indexes and level of Hcy in the Metoprolol group were signifieant（P〈0.05）.Conclusion： Metoprolol and Simvastatin both can improve the blood pressure, heart rate, HRV and Hcy of patients with CHD, but Metoprolol in the improvement of HRV frequency index and Hcy level has a good effect.
出处
《中外医学研究》
2015年第17期1-4,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
