摘要
目的:探讨肺泡蛋白沉积症的诊断方法和治疗策略。方法:回顾笔者所在医院2例诊断为肺泡蛋白沉积症的患者资料,分析其临床特征、影像学改变以及病理结果,并结合文献进行复习。结果:肺泡蛋白沉积症病程迁延,常见症状为劳力性呼吸困难及咳嗽,典型胸部CT可见铺路石征改变,支气管肺泡灌洗液或肺组织病理可见肺泡腔内PAS染色阳性无定型颗粒状物质。结论:肺泡蛋白沉积症临床表现缺乏特异性,肺组织病理及支气管肺泡灌洗液细胞学检查在诊断中具有极高价值,大多数患者经全肺灌洗或支气管肺泡灌洗治疗后可获得较好疗效。
Objective： To discuss the diagnosis and treatment strategies of pulmonary alveolar proteinosis（PAP） patients.Method： The clinical data of 2 cases diagnosed as pulmonary alveolar proteinosis in our hospital were reported and relevant literatures were reviewed.The clinical manifestations, radiological and histopathology findings were respectively analyzed.Result： With a prolonged course, common symptoms of PAP were dyspnea and cough, GT-scan indicated typical ＇ crazy paving＇ pattern and histopathology of lung or broncho alveolar lavage fluid revealed patchy PAS positive material within alveolar spaces. Conclusion： The manifestations of PAP are not specific.Typical findings in histopathology of the lung tissue and cytological analysis of BALF are vital to diagnosis. Whole lung lavagc or broncho alveolar lavage is effective in most PAP patients.
出处
《中外医学研究》
2015年第17期162-164,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
