自拟益气养阴通络方联合厄贝沙坦治疗早期糖尿病肾病128例临床观察

Clinical observation on treating 128 cases of early diabetic nephropathy with the Yiqi Yangsheng Tongluo decoction plus Irbesartan

目的:探讨自拟益气养阴通络方联合厄贝沙坦治疗早期糖尿病肾病的临床效果。方法:选择我科收治的128例早期糖尿病肾病患者,随机分为两组,其中观察组予以自拟益气养阴通络方联合厄贝沙坦治疗,对照组单纯予以厄贝沙坦治疗,每组各64例,治疗后观察两组患者疗效及比较肾功能指标。结果:与对照组有效率50.00%比较,观察组患者有效率68.75%升高明显,差异具有统计学意义(P<0.05)。治疗前,两组患者的24h、SCr、BUN比较,差异均无统计学意义(P>0.05);治疗后,观察组的各项指标虽均低于对照组,但差异均无统计学意义(P>0.05)。同组比较,治疗后,两组各项指标均较治疗前降低,差异具有统计学意义(P<0.05)。结论:自拟益气养阴通络方联合厄贝沙坦可有效提高治疗早期糖尿病肾病的疗效,但对于肾功能改善不明显。

Objective： To discuss clinical effect of Yiqi Yangyin Tongluo decoction combined with irbesartan on diabetic nephropathy. Methods： 128 early diabetic nephropathy patients who were treated in our department were selected and divided into 2 groups, observed group were given Yiqi Yangyin Tongluo decoction plus irbesartan, control group were simply given irbesartan, 64 cases in each group. Results： For clinical efficiency, control group was 50.00%, observed group was 68.75%, the difference come with statistical significance （P〈0.05）. Compared within group, after treatment, both group＇s index lower than control group, with statistical significances （P〈O.05）. Conclusion： Self-designed Yiqi Yangyin Tongluo decoction plus irbesartan can effectively improve early diabetic nephropathy, but can＇t obviously improve renal function.