摘要
nano 金属氧化物的抗菌剂性质(ZnO， CuO ) 基于反应的氧种类(ROS ) 的形成。这个工作表明这些 nano 金属氧化物的抗菌剂性质强烈依赖于他们的水晶的结构。nanooxides 的抗菌剂活动对通常引起医院的感染的细菌的四种类型被测试。sonochemical 方法在纺织品上为 nanooxides 而且到他们的涂层的合成被使用不仅。与商业、 sonochemically 准备的 nano 金属氧化物涂的纺织品的抗菌剂性质被评估并且比较。毒性在人的肺房间和两栖动物胚胎上被评估，作为为吸入和水的毒物学的代表性的模型。sonochemically 准备的金属 nanooxides 比有一样的粒子尺寸范围的商业地可得到的金属氧化物是更好的抗菌剂。有更多的缺点和更少的组织结构的雏晶是更多，这被发现有毒。ROS 的形成被电子纺纱学习为两个的回声(ESR ) 大小 sonochemically 准备了并且 ZnO/CuO nanoparticles 的商业样品。激进的种类的生产的重要增加在更有缺点的、 sonochemically 准备的样品被发现，作为与商业的相比。因为 nanoparticle 缺点的调整影响了他们的毒性，设计更安全的 nano 抗菌剂的可能性被显示。
The antibacterial properties of nano-metal oxides （ZnO, CuO） are based on the formation of reactive oxygen species （ROS）. This work reveals that the antibacterial properties of these nano-metal oxides are strongly dependent on their crystalline structure. The antibacterial activity of the nanooxides was tested against four types of bacteria that commonly cause nosocomial infections. The sonochemical method was applied not only for synthesis of nanooxides but also to their coating on textiles. The antibacterial properties of textiles coated with commercial and sonochemically prepared nano-metal oxides were evaluated and compared. The toxicity was evaluated on human lung cells and amphibian embryos, as representative models for inhalation and aquatic toxicology. The sonochemically prepared metal nanooxides are better antimicrobials than commercially available metal oxides with the same particle size range. It was found that the crystallites which have more defects and less organized structure are more toxic. The formation of ROS was studied by electron spin resonance （ESR） measurements for both the sonochemically prepared and commercial samples of ZnO/CuO nanoparticles. A significant increase in the production of radical species was found in the more defective, sonochemically prepared samples, as compared to the commercial ones. Since modulation of the nanoparticle defects influenced their toxicity, the possibility of engineering safer nano-antibacterials is indicated.
