摘要
mesoporous 硅石 / 黄金(MSN/Au ) nanocomposite 为明确地目标为肿瘤房间的控制相片的药交货被设计。MSN/Au nanocomposite 由基于 MSN 的药搬运人组成，金 nanoparticle (AuNP ) 基于指示物。当基于 MSN 的药搬运人是 mesoporous 硅石时， nanoparticle 与相片可切换的偶氮苯使不能调动(偶氮) 一半，基于 AuNP 的指示物是与矩阵 metalloproteinase (MMP ) 修改的熄灭荧光的 AuNP 底层并且 poly (乙烯乙二醇) 。二种 nanoparticles 被连接由一， cyclodextrin (， CD ) 更暗淡的桥牌。在 vitro，研究证明 nanocomposite 明确地与肿瘤地点 overexpressing MMP-2 交往了，为释放的随后的紫外轻照耀的启用的指导它骗诱药。通过基于 AuNP 的指示物和基于 MSN 的药搬运人的集成， MSN/Au nanocomposite 能精确本地化释放的药到肿瘤地点，显著地从而改进治疗学的功效。
A mesoporous silica/gold （MSN/Au） nanocomposite was designed for photo- controlled drug delivery targeted specifically at tumor cells. The MSN/Au nanocomposite was composed of MSN-based drug carriers and gold nanoparticle （AuNP）-based indicators. While the MSN-based drug carrier was a mesoporous silica nanoparticle immobilized with photo-switchable azobenzene （Azo） moieties, the AuNP-based indicator was a fluorescence-quenched AuNP modified with a matrix metalloproteinase （MMP） substrate and poly（ethylene glycol）. The two kinds of nanoparticles were connected by an α,β cyclodextrin （α,β CD） dimer ＂bridge.＂ In vitro studies demonstrated that the nanocomposite specifically interacted with tumor sites overexpressing MMP-2, which enabled guidance of the subsequent UV light irradiation for releasing entrapped drugs. Through integration of the AuNP-based indicator and the MSN-based drug carrier, the MSN/Au nanocomposite could precisely localize the released drug to tumor sites, thereby significantly improving therapeutic efficacy.
基金
This work was financially supported by the National Natural Science Foundation of China （Nos. 51125014 and 51233003）, National Basic Research Program of China （No. 2011CB606202）, the Ministry of Education of China （No. 20120141130003）, and Fundamental Research Funds for the Central Universities of China （Nos. 2014203020201 and 2014203020204）.
