摘要
A multifunctional, dual-drug carrier platform was successfully constructed. Core-sheU structured NaGdF4：Yb/Er@NaGdF4：Yb@mSiO2-polyethylene glycol （abbreviated as UCNPS） nanopartides loaded with the antiturnor drug, doxorubicin （DOX） were incorporated into poly（^-caprolactone） （PCL） and gelatin loaded with antiphlogistic drug, indomethacin （MC） to form nanofibrous fabrics （labeled as MC/UCNPS/DOX） via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide （SiO2） and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4：Yb/Er@NaGdF4：Yb embedded in MCfldCNPS/DOX invivo.
一个多功能的、双药的搬运人平台成功地被构造。核心壳组织了 NaGdF <sub>4</sub>:Yb/Er@NaGdF<sub>4</sub>:Yb@mSiO<sub>2</sub>-polyethylene 乙二醇(作为 UCNPS 缩短了) 与 antitumor 药装载的 nanoparticles， doxorubicin (纪录影片) 被合并到 poly (-caprolactone)( 打印机控制语言) 和明胶与消炎的药装载了，消炎痛(MC ) 到形式 nanofibrous 织物(作为 MC/UCNPS/DOX 标记) 经由 electrospinning 过程。结果的多功能的旋转片能通过手术作为 orthotopic 化疗在老鼠的肿瘤地点直接被植入由从 mesoporous 硅二氧化物的控制版本纪录影片(通过 NaGdF <sub>4</sub>:Yb/Er@NaGdF<sub>4</sub>:Yb 的双模型的成像在 vivo 在 MC/UCNPS/DOX 嵌入的 SiO <sub>2</sub>) 和 upconversion fluorescence/magnetic 回声。
基金
This project is financially supported by the National Natural Science Foundation of China （NSFC, Nos. 51332008, 51372243, 51422209, and 51202239）, the National Basic Research Program of China （No. 2014CB643803）.
