摘要
目的：本研究旨在探讨血清半乳糖凝集素-3水平与2型糖尿病患者合并冠心病的相关性。方法本研究共纳入177例2型糖尿病患者，根据患者是否罹患冠心病将所有患者分为冠心病组（D-CAD＋,n=65）及非冠心病组（D-CAD-,n=112），另选取单纯冠心病患者（CAD＋,n=73）及健康成人（ND,n=50）作为对照组。采用酶联免疫吸附（ELISA）法测量各组血清半乳糖凝集素-3水平。结果D-CAD＋组患者血清Gal-3水平表达最高（10.27±2.53）ng/ml，其次为CAD＋组（5.72±0.64）ng/ml，再次为D-CAD-组（2.64±0.36）ng/ml，ND组表达最低（1.17±0.21）ng/ml。D-CAD＋组患者血清Gal-3表达水平较CAD＋组显著升高，而后者显著高于D-CAD-组，同时上述三组均高于ND组，差异均有统计学意义（P＆lt;0.05）。多元Logistic回归分析显示高血清半乳糖凝集素-3水平与2型糖尿病患者存在冠心病呈独立相关（优势比2.375,95%可信区间1.258～3.952；P＆lt;0.01）。结论血清半乳糖凝集素-3水平是预测2型糖尿病患者合并冠心病的独立危险因子，血清半乳糖凝集素-3有望可能成为预测2型糖尿病患者发生冠心病风险的重要的生物学标记物。
Objective To explore whether serum galectin-3 （Gal-3） levels are associated with the presence of coronary artery disease （CAD） in patients with type 2 diabetes （DM2）. Method A total of 177 patients with DM2 were enrolled in the present study. All the patients were classified as D-CAD＋ （n=65） or D-CAD- （n=112） group based on the presence of CAD or not.73 patients with CAD and 50 healthy adults served as the control group. Serum Gal-3 levels were determined by enzyme-linked immunosorbent assay （ELISA）.Result The highest serum Gal-3 expression level of （10.27±2.53）ng/ml was present in D-CAD＋ patients, followed by the CAD＋ patients with the level of （5.72±0.64）ng/ml and the D-CAD- patients with the level of （2.64 ±0.36）ng/ml, while the lowest one of （1.17±0.21）ng/ml was present in healthy adults. D-CAD＋patients had significantly higher Serum Gal-3 levels than CAD＋ patients, and the latter had significantly higher Serum Gal-3 levels than D-CAD- patients. Serum Gal-3 levels in all three groups above were significantly higher in healthy adults, which presented statistically significant differences （P＆lt;0.05）.Multivariate logistic regression demonstrated that higher Gal-3 levels were independently associated with the presence of CAD （OR 2.375, 95% CI 1.258~3.952,P＆lt;0.01） in patients with DM2.Conclusion Serum Gal-3 is an independent risk factor for CAD in DM2 patients, which indicates that Gal-3 might be a useful biomarker for predicting the presence of CAD in patients with DM2.
出处
《创伤与急诊电子杂志》
2015年第2期13-16,共4页
Journal of Trauma and Emergency(Electronic Version)
