宫颈癌患者的病原菌分布分析

Analysis of pathogen distribution in patients with cervical cancer

目的分析生殖道病原菌感染在人乳头瘤病毒(HPV)高危宫颈癌患者中的分布。方法回顾性分析经病理证实为宫颈癌的355例新发病例,作为试验组,对照组选自同期就诊的慢性宫颈炎的538例患者。2组患者在诊断前均行阴道分泌物病原菌培养及HPV-DNA检测,统计2组患者的病原菌分布及HPV检测结果。结果观察组检出HPV阳性患者214例(60.28%),对照组检出HPV阳性患者226例(42.01%),差异有统计学意义(P<0.05)。2组检出最多的均为真菌、革兰氏阴性菌、革兰氏阳性菌,其中白色念珠菌数量最多;病原菌检出率及构成比差异均有统计学意义(P<0.05)。2组HPV检测结果相比,差异有统计学意义(P<0.05);2组HPV检测阳性患者的病原菌培养结果,差异有统计学意义(P<0.05)。结论感染为宫颈癌发生的危险因素,生殖道病原菌感染协同HPV感染增加宫颈癌的发生率。

Objective To analyze the distribution of reproductive tract infection pathogens in cervical cancer patients with high risk of the hu-man papilloma virus （ HPV）.Methods A total of 355 cases that patho-logically confirmed as cervical cancer （ the observation group） were retro-spectively analyzed, and 538 patients with chronic cervicitis were select-ed as control group from the same period.Patients in two groups all re-ceived vaginal secretions pathogen culture and HPV-DNA testing before the diagnosis, and then the distribution of pathogens and HPV test results were compared.Results In the observation group, 214 cases were de-tected HPV-positive （ 60.28%） , 226 cases detected in control group （42.01%）, and the difference was statistically significant （P〈0.05）. Fungus, gram-negative bacteria, and gram-positive bacteria were most frequently detected, and Candida albicans accounted for the major part in two groups.The pathogen detection rate and constitution ratio of the two groups were statistically different （ P 〈0.05 ） , as well as the results of HPV detection.The pathogen culture results of HPV-positive patients in two groups were statistically different（ P〈0.05）.Conclusion Infection is a risk factor for cervical cancer occurrence, and genital tract pathogen together HPV infection increased the occurrence rate of cervical cancer.