左氧氟沙星序贯治疗Ⅲa型前列腺炎的药物经济学分析

Cost-effectiveness analysis of sequential therapy of levofloxacin in the treatment of type Ⅲa prostatitis

目的评价左氧氟沙星序贯治疗Ⅲa型前列腺炎的成本-效果。方法筛选出280例Ⅲa型前列腺炎患者,随机分为序贯组和对照组,序贯组,静脉滴注左氧氟沙星注射液500 mg,7 d后改为口服左氧氟沙星片500 mg;对照组,静脉滴注左氧氟沙星注射液500 mg,均每日1次。观察临床疗效和不良反应,并进行成本-效果分析。结果序贯组和对照组的临床疗效比较差异无统计学意义(P>0.05)。对照组的费用显著高于序贯组(P<0.05),序贯组的成本效果比显著低于对照组(P<0.05),序贯组的敏感度也显著低于对照组(P<0.05),序贯组与对照组的药物不良反应发生率分别为5.71%,15.71%(P<0.05)。结论左氧氟沙星序贯治疗Ⅲa型前列腺炎具显著的成本效果优势和安全性,是有效、经济及合理的药物治疗方案。

Objective To evaluate the cost-effectiveness of sequential therapy of levofloxacin in the treatment of type Ⅲa prostatitis.Methods A total of 280 in-patients diagnosed typeⅢa prostatitis were enrolled in this study and randomized to administer with either levofloxacin 500 mg（ n =140 ） for intravenous injection once daily for 28 days （ control group） or administered of levofloxacin injection 500 mg （ n=140 ） once daily for 7 days followed by oral levofloxacin 500 mg once daily for 21 days（ sequential group）.Clinical results and safety were observed and cost-effectiveness analysis was made after 4 -week therapeutic dura-tion.Results The clinical effective rates showed no significant difference between 2 groups （ P〈0.05 ）.But cost -effectiveness ratio and sensitivity analysis in sequential group was significantly lower than that in control group（P〈0.05）.The adverse drug reaction rates in con-trol group （ 15.71%） and sequential group （ 5.71%） showed significant difference between 2 groups （ P〈0.05 ）.Conclusion The sequential therapy with the antibiotic therapeutic of levofloxacin 500 mg once daily achieved similar clinical efficacy to mono-therapy and offered an eco-nomic superiority and less adverse reactions in the treatment of type Ⅲa prostatitis.