化痰熄风法治疗癫痫

Effects of Method of Huatan Xifeng to Patients with Epilepsy

目的:观察化痰熄风法治疗癫痫的中医证候疗效及生活质量变化。方法:将61例癫痫患者采用随机数字表法分为治疗组30例与对照组31例。两组均给予西医基础治疗,治疗组在西医基础治疗上加服中医化痰熄风方药,每日1剂,水煎服,两组疗程均为3个月。比较治疗前后两组中医证候疗效及癫痫患者生活质量量表(QOLIE-31)。结果:治疗组30例,临床痊愈0例,显效4例,有效21例,无效5例,总有效率为83.33%,对照组31例,临床痊愈0例,显效0例,有效14例,无效17例,总有效率为45.16%,两组比较差异有统计学意义(P<0.01)。治疗后,两组QOLIE-31总分较治疗前均有上升(P<0.01),但两组之间差异无统计学意义。进一步因子分析,治疗后治疗组在精神状态、社会功能、认知功能、药物影响、发作担忧、总体健康感6个方面得分高于治疗前(P<0.05),情绪状态得分差异无统计学意义;对照组在精神状态、社会功能、认知功能、药物影响、发作担忧5个方面得分高于治疗前(P<0.05),情绪状态及总体健康感得分差异无统计学意义;两组比较,治疗组在精神状态、发作担忧和总体健康感3个方面得分高于对照组,差异有统计学意义(P<0.05)。结论:化痰熄风法治疗癫痫能有效改善患者的精神、体力及睡眠等情况,提高生活质量。

Objective： The aim of this study was to observe the clinical therapeutic effect and the change of life quality of Huatan Xifeng method in patients with epilepsy the method. Method： The sixty-one patients with epilesy who met the inclusion criteria were randomized divided into treatment group and control group. Both groups were treated by the routine antiepileptic drugs. The patients in treatment group received traditional Chinese medicine （TCM） soup according to the method of Huatan Xifeng, additionally. The course of treatment in both group lasted for 3 months. Clinical therapeutic effect and the change of the score of the quality of life in epilepsy-31 （QOLIE-31） were compared. Result： The clinical efficacy in treatment group was 0 case as clinical recovery, g cases as markedly effective, 21 cases as effective, and 5 cases as invalid. In control group, the clinical efficacy was 0 case as clinical recovery, 0 case as markedly effective, 14 cases as effectiv, 17 cases as invalid. The total effective rate in treatment group was 83.33% , while in control group it was 45. 16% , with statistically significant difference （P 〈0.01 ）. After treatment, the scores of QOLIE-31 in both group were higher than before treatment. The difference was statistically significant （P 〈 0.01 ）. But the difference between two groups was not statistically significant. Further analysis of each factors： in treatment group, the difference in six aspects including spiritual state, social function, cognitive function, the effect of drugs, worry to seizure and feeling of health were statistically significant （P 〈 0.05）. The difference in emotional state was not statistically significant. In control group, the difference in five aspects including spiritual state, social function, cognitive function, the effect of drugs, worry to seizure were statistically significant （P 〈 0.05）. The difference in emotional state and feeling of health was not statistically significant. In the third month, the scores of QOLIE-3 in treatment group in three aspects spiritual state, worry to seizure and feeling of health were higher than in control group. The difference was statistically significant （P 〈 O. 05 ）. Conclusion： The TCM soup according to the method of Huatan Xifeng with routine antiepileptic drugs can ameliorates the state of the epilepsy patient, such as spirit, physical strength and sleep, and improve the quality of life in epilepsy patients.