基于关联规则和复杂系统熵聚类的膝骨关节炎用药规律研究

Analysis on Medication Rule in Herbal Prescriptions for Knee Osteoarthritis Based on Apriori and Clustering Algorithm

目的:基于中医传承辅助平台(TCMISS)软件,分析膝骨关节炎中药处方的用药规律。方法:收集近5年治疗膝骨关节炎文献中的中药处方,采用关联规则apriori算法、复杂系统熵聚类等无监督数据挖掘方法,分析处方中各种药物的使用频次、归经及药物间的关联规则,挖掘药物核心组合和新处方。结果:对筛选出的263个中药处方进行分析,确定处方中药物的使用频次、归经及药物间的关联规则,挖掘出16个核心组合和4首新处方。结论:膝骨关节炎常用的药物为活血化瘀药、补血药、补气药、补阳药、祛风湿散寒药等,具有补肾、活血功效的药物是主要组成部分。药物归经主要为肝、肾两经。治法主要是补益肝肾、活血化瘀。中医传承辅助平台(TCMISS)有助于处方的用药规律研究。

Objective： The aim of this study was to analyze the medication rule in herbal prescriptions for knee osteoarthritis by using Chinese medicine inheritance support system （TCMISS）. Method： The herbal prescriptions for knee osteoarthritis from papers were collected, then the data were input into TCMISS and composition principles were analyzed by using data mining methods such as revised mutual information, complex system entropy cluster and unsupervised hierarchical cluster. Result： Based on the analysis of 263 herbal prescriptions, the frequency and meridian entry distributions of each herb were found, association rules among the herbs were computed, 16 core combinations and 4 new prescriptions were mined from the database. Conclusion： The common Chinese medicines used for knee osteoarthritis included blood-activating and stasis-resolving medicine, blood-tonifying medicine, qi-tonifying medicine, wind-dampness-dispelling and cold-dispersing medicine. The major components of the Chinese medicines for knee osteoarthritis were the medicines which have the function of tonifying the kidney or activating blood. The meridian entry distributions of herbs are composed of liver meridian and kidney meridian. The method of treatment for knee osteoarthritis are to regulate the liver and supplement the kidney, activate blood and resolve stasis. TCMISS contribute to the study of composition principle lawof herbal prescriptions.