原发性肝癌术中植入氟尿嘧啶缓释剂的临床疗效及对患者血清学指标的影响

Effect of intraoperative fluorouracil implants on primary liver cancer and its impact on serological indexes

目的分析原发性肝癌术中植入氟尿嘧啶缓释剂的临床疗效及对患者血清学指标的影响。方法选择在河南科技大学附属三门峡市中心医院接受手术治疗的原发性肝癌患者作为研究对象,随机分为接受单纯手术治疗的对照组,以及接受手术切除联合术中氟尿嘧啶植入剂治疗的观察组。比较两组患者的病灶变化、血清相关指标水平及T细胞亚群水平等差异。结果观察组患者接受手术切除联合术中氟尿嘧啶植入剂治疗后,CR及PR率显著高于对照组患者(P<0.05)。观察组患者接受治疗后的血清AFP、EC、VEGF、endostatin水平均明显低于对照组患者(P<0.05)。观察组患者接受手术切除联合术中氟尿嘧啶植入剂治疗后,CD3+、CD4+、CD4+/CD8+水平高于对照组,CD8+水平低于对照组(P<0.05)。结论手术切除联合术中氟尿嘧啶植入剂可以显著提升原发性肝癌治疗效果,降低血清肿瘤侵袭相关指标水平,增强患者免疫力。

[ Objective ] To analyze the effect of intraoperative fluorouracil implants on primary liver cancer and its impact on serological indexes. [Methods] One hundred and sixteen cases of primary liver cancer patients in our hospital who underwent surgery were enrolled as research subjects, and randomly divided into control group with surgery alone, and observation group with surgical excision combined with intraoperative fluorouraeil implants. The change of lesions, serum levels of related indexes and T cell subgroup levels in both groups were compared. [ Results ] The CR and PR rates in the observation group were significantly higher than those in the control group （P 〈 0.05）. The serum AFP, EC, vascular endothelial growth factor （VEGF） and endostatin levels in the observation group were significantly lower than those in the control group （P 〈 0.05）. The CD^3＋, CD^4＋ and CD^4＋/CD^8＋ levels in the observation group were higher than those in the control group, while the CD^8＋ level was lower （P 〈 0.05）. [ Conclusions ] Surgical removal combined with intraoperative fluorouracil implants could significantly improve the effect of treatment for primary liver cancer, reduce the serum levels of tumor invasion related indicators, and improve immune function of the 9atients.