摘要
目的:探讨不同频率重复经颅磁刺激(r TMS)对轻中度阿尔茨海默病(AD)患者认知功能的影响。方法:82例轻中度AD患者,随机分为高频组、低频组和对照组,3组患者分别给予20、1 Hz和伪刺激,疗程为4周。治疗前后分别采用阿尔茨海默病评定量表认知分量表(ADAS-Cog)、事件相关电位及脑电图检测进行疗效评定。结果:与治疗前相比,治疗4周末高频组和低频组ADAS-Cog总分、语言因子分、记忆因子分明显减低、事件相关电位及脑电图指标明显改善,对照组各评估指标较治疗前差异无显著性。组间比较,高频组疗效优于低频组。结论:r TMS可改善AD患者的认知功能,高频刺激的效果更佳。
Objective To assess the effect of repetitive transcranial magnetic stimulation （rTMS） with different frequency on cognitive function in patients with mild or moderate Alzheimer＇s disease.Methods Eighty- two patients were randomly divided into 20Hz rTMS group, 1Hz rTMS group and control group, respectively. The effect of three groups was compared after 4-week treatment. Results Apparent curative effect was observed in 20Hz rTMS group and 1Hz rTMS groups, particularly in 20Hz group while no significant improvement was found in control group. Conclusion rTMS benefits the improvement of cognitive function in patients with AD, and particularly good effect can be achieved with high- frequency stimulation.
出处
《实用医学杂志》
CAS
北大核心
2015年第10期1624-1627,共4页
The Journal of Practical Medicine
基金
无锡市科技发展资金项目(编号:CSE31N1323)
关键词
阿尔茨海默病
重复经颅磁刺激
认知功能
Alzheimer＇s disease
Repetitive transcranial magnetic stimulation
Cognitive function
