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初诊2型糖尿病患者血浆内脂素水平与糖脂代谢的相关性研究 被引量:1

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摘要 选择2013年4月~2014年4月在我院内分泌科住院的2型糖尿病(T2DM组)患者66例及我院体检的正常健康人(NC组)60例,分别测空腹血糖(FPG)、餐后2小时血糖(2h PG)、空腹胰岛素(FIns)、餐后2小时胰岛素(2h Ins)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及糖化血红蛋白(Hb A1c),计算腰臀比(WHR)、体重指数(BMI)。采用酶联免疫法(ELISA)测定T2DM患者和正常健康人血清visfatin水平。结果 1T2DM组血清visfatin水平较NC组明显升高(P〈0.01),差异有统计学意义。2Pearson相关分析显示Visfatin与BM I(r=0.354,P〈0.01)、WHR(r=0.582,P〈0.01)、LDL-C(r=0.424,P〈0.01)及FBG(r=-0.305,P〈0.05)呈正相关。结论 2型糖尿病病程中visfatin的升高可能与肥胖有关,且visfatin在2型糖尿病的发生发展过程中存在作用。
出处 《实用糖尿病杂志》 2015年第3期49-50,共2页 Journal of Practical Diabetology
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  • 1American Diabetes Association. Report of the expert committee on the diagnosis and classification of diabetes mellitus[J]. Diabetes Care, 1997,20 : 1183-1197.
  • 2Fukuhara A, Matsuda M, Nishizawa M, etal. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin[J]. Science, 2005,307 (5708) : 426-430.
  • 3Lopez-Bermejo A, Chico-Julid B, Ferndndez-Balsells M, et al. Serum visfatin increases with progressive β-cell deterioration[J]. Diabetes, 2006,55 (10) : 2871-2875.
  • 4Chen MP, Chung FM, Chang DM, et al. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus[J]. J Clin Endocrinol Metab, 2006,91 (1) :295-299.
  • 5Jian WX, Luo TH, Gu YY, etal. The visfatin gene is associated with glucose and lipid metabolism in a Chinese population[J]. Diabet Med, 2006,23 (9) : 967-973.
  • 6Trayhum P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc,2001,60:329-339.
  • 7Hug C, Lodish HF. Visfatin: A new adipokine. Science, 2005,307:366-367.
  • 8Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: A protein secreted by visceral fat that mimics the effects of insulin. Science, 2005,307:426-430.
  • 9Chen MP, Chung FM, Chang DM, et al. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab, 2006,91:295-299.
  • 10Kralisch S, Klein J, Lossner U, et al. Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes. J Endocrinol, 2005,185:R1-8.

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