胃肠安丸对功能性消化不良肝郁脾虚模型大鼠胃排空的影响

Effect of Weichang'an pills on gastric emptying in rat model of functional dyspepsia and stagnation of liver qi and spleen deficiency

目的:观察胃肠安丸对功能性消化不良(FD)肝郁脾虚模型大鼠胃排空的影响。方法:将50只SD大鼠随机分为正常对照组,模型组,胃肠安丸高、低剂量组和吗丁啉组,每组10只。除正常对照组外,其余各组均采用"夹尾激怒加不规律饮食法"制作FD肝郁脾虚型大鼠模型。造模成功后,胃肠安丸高、低剂量组分别灌胃胃肠安丸混悬液50.4mg/kg·d、25.2mg/kg·d,吗丁啉组灌服吗丁啉混悬液2.7mg/kg·d,正常对照组与模型组灌服等体积生理盐水,每天1次,连续给药7d。检测胃内残留率,判定各组大鼠的胃排空力水平。结果:与正常对照组相比,模型组胃内残留率增高,差异有统计学意义(P<0.05);与模型组相比,胃肠安丸高、低剂量组及吗丁啉组大鼠胃内残留率均降低,差异有统计学意义(P<0.05)。结论:胃肠安丸可以有效降低FD肝郁脾虚模型大鼠的胃内残留率,促进胃排空。

Objective： To observe the effect of Weichang＇an pills on gastric emptying in a rat model of functional dyspepsia（ FD） and stagnation of liver qi and spleen deficiency. Methods： Fifty Sprague- Dawley rats were equally and randomly divided into normal control group,model group,high- and low- dose Weichang＇an pill groups,and motilium group. A rat model of FD and stagnation of liver qi and spleen deficiency was established in each group by＂irritating by tail clamping combined with irregular diet ＂. After modeling,the rats in the high- and low- dose Weichang＇an pill groups were intragastrically administered with suspension of Weichang＇an pills at 50. 4mg / kg·d and25. 2mg / kg·d,the rats in the motilium group with suspension of motilium at 2. 7mg / kg·d,and the rats in the normal control group and model group with normal saline at the same volume. Each group was treated once daily for 7consecutive days. Gastric residual rate was measured to determine the capacity of gastric emptying in each group. Results： Compared with the normal control group,the model group had a significantly increased gastric residual rate（ P〈0. 05）; the gastric residual rate was significantly lower in the high- and low- dose Weichang＇an pill groups and Motilium group than in the model group（ P〈0. 05）. Conclusion： Weichang＇an pills can effectively decrease the gastric residual rate in the rat model of FD and stagnation of liver qi and spleen deficiency to promote gastric emptying.