聚乙二醇修饰壳聚糖在生物医学领域的研究进展

Research Progress in Polyethylene Glycol Modified Chitosan Applied in Biomedical Field

目的：为聚乙二醇修饰壳聚糖的深入研究提供参考。方法：通过查阅、检索2004-2014年国内外相关文献及资料,并进行总结归纳。结果：聚乙二醇修饰壳聚糖的方法多样,可应用于制备纳米药物载体、制备基因治疗的载体、温敏性水凝胶、高分子前药以及组织工程修复材料。结论：聚乙二醇修饰的壳聚糖在生物医药领域研究广泛,但相关研究仅限于体外,体内研究需进一步系统和深入。

Objective： To provide reference for the intensive study on polyethylene glycol modified chitosan. Methods： The related literatures at home and abroad were looked up and retrieved from 2004 to 2014, and the related contents were summarized. Results： The methods for the preparation of polyethylene glycol modified chitosan were various. Polyethylene glycol modified ehitosan could be used as the carrier for nano-drug and gene therapy, the base of temperature-sensitive hydrogel, polymeric prodrug and the repair material of tissue engineering. Conclusion： Polyethylene glycol modified chitosan can he wildely used in biomedical field. However, the related research is only in vitro. The in vivo studies should be further systematic and intensive.