期刊文献+

阿托伐他汀对94例糖尿病视网膜病变患者炎症因子的影响 被引量:3

Effect of Atorvastatin on inflammatory factors in 94 patients with diabetic retinopathy
原文传递
导出
摘要 糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病微血管并发症之一,具有特征性的眼底改变,是引起视力下降和失明的主要原因,每年导致12 000~24 000人失明[1],但其病因及发病机制目前尚未完全阐明。近年研究表明DR是一种慢性低度性炎症性疾病,炎症因子在DR的发生发展中起重要作用。国内外研究显示,他汀类药物具有调脂外的抗炎作用。(high sensitivity C reactive protein,hs-CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、细胞间黏附分子-1(intercellular adhesion molecule-1,ICAM-1)的浓度变化作为指标,探讨阿托伐他汀对早期DR患者的抗炎作用。
出处 《武警后勤学院学报(医学版)》 CAS 2015年第5期386-388,共3页 Journal of Logistics University of PAP(Medical Sciences)
基金 廊坊市科技发展计划项目(2012013024)
  • 相关文献

参考文献19

  • 1Santos JM, Mohammad G, Zhong Q, eta/. Diabetic retinopa- thy, superoxide damage and antioxidants[J]. Curr Pharm Bio- technol, 2011, 12(3):352-361.
  • 2Antonetti DA, Klein R, Gardner TW. Diabetic retinopathy[J]. N Engl J Med, 2012, 366(13):1227-1239.
  • 3Rangasamy S, McGuire PG, Das A. Diabetic retinopathy and inflammation:novel therapeutic targets[J]. Middle East Aft J Ophthalmol, 2012, 19(1):52-59.
  • 4Huang H, Gandhi JK, Zhong X, et al. TNFalpha is required for late BRB breakdown in diabetic retinopathy,and its inhi- bition prevents leukostasis and protects vessels and neurons from apoptosis[J]. Invest Ophthalmol Vis Sci, 2011, 52(3): 1336-1344.
  • 5Koleva-Georgieva DN, Sivkova NP, Terzieva D. Serum in- flammatory eytokines IL-lheta, IL-6, TNF-alpha and VEGF have influence on the development of diabetic reti- nopathy[J].Folia Med(Plovdiv), 2011, 53(2):44-50.
  • 6Cui B, Sun JH, Xiang FF, et al. Aquaporin 4 knockdow n ex- acerbates streptozotocin- induced diabetic retinopathy through aggravating inflammatory response[J]. Exp Eye Res, 2012, 98(1):37-43.
  • 7Salam A, Mathew R, Sivaprasad S. Treatment of proliferative diabetic retinopathy with anti-VEGF agents[J]. Acta Oph- thalmol, 2011, 89(5):405-411.
  • 8El-Remessy AB, Rajesh M, Mukhopadhyay P, et M. Canna- binoid 1 receptor activation contributes to vascular inflam- mation and cell death in a mouse model of diabetic retinopa- thy and a human retinal cell line[J]. Diabetologia, 2011, 54 (6):1567-1578.
  • 9van HeckeMV, Dekker JM, NijpelsG, et al. Inflammation andendothelial dysfunction are associatedwith retiropathy:the- Hoom Study[J]. Diabetologia, 2005, 48(7): 1300-1306.
  • 10Joussen AM, Doehmen S, Le ML, et al. TNF-ct mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term istopathological altera- tions[J]. Mol Vis, 2009, 25(15):1418-1428.

二级参考文献26

共引文献21

同被引文献27

引证文献3

二级引证文献43

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部