精神分裂症对代谢综合征发病的影响

Effects of Schizophrenia to the Incidence of Metabolic Syndrome

目的:探讨精神分裂症对代谢综合征发病的影响。方法:选取2012年1月至2014年8月份来我院救治的精神分裂症患者150例,选取同时期住院的无精神分裂症的患者105例作为对照组,按是否患有代谢综合征将150例精神分裂症患者分为有代谢综合征组与代谢综合征组,分析比较实验组内两组患者的性别、年龄、服药种类、血糖及血脂等基本的临床资料。结果:实验组患者MS的患病率明显高于对照组患者。实验组患者的年龄、吸烟史、血压(BP)、空腹血糖(FPG)、体质指数(BMI)、病程及三酰甘油(TG)均高于对照组;实验组患者的高密度脂蛋白胆固醇(HDL-C)低于对照组。多因素回归分析显示精神分裂症患者合并代谢综合征的独立危险因素有:年龄、性别、病程及吸烟史。结论:病程长及有吸烟史的大龄女性精神病分裂症患者易患代谢综合征,应特别注意。

Objective： To probe the effect of schizophrenia to the incidence of metabolic syndrome.Methods：150 cases patients with schizophrenia were selected in our hospital from January 2012 to August 2014.150 cases patients without schizophrenia in the sames period were selected as the control group.All the experimental patients were divided into experimental group and control group according to whether suffering from metabolic syndrome.The gender,age,medication type,blood sugar and lipids of the two groups were analysed and compared.Results：The MS prevalence of the experimental group was significantly higher than the controlal group.The gae,smoking history,BP,FPG,BMI,duration and TG of the experimental group were higher than the control group.The HDL-C of the experimental group was lower than the control group.Multivariate regression analysis showed that the gae,gender,disease duration and smoking history were the independent risk factors of schizophrenia to the patients with of schizophrenia.Conclusin：Longer duration,smoking history and older female schizophrenia patients are susceptible to metabolic syndrome.Special attention should to be paied to these patients.