曲美他嗪对休克患者肾脏功能指标的改善作用

Improvement Effect of Trimetazidine on Renal Function Indicators in Patients with Shock

目的:探讨曲美他嗪对休克患者肾脏功能指标的改善作用。方法:选取2011年4月至2014年3月我院救治的160例休克患者,随机分为观察组和对照组,各组均常规抗休克治疗,观察组加用盐酸曲美他嗪,对照组加用安慰剂。记录每小时尿量等6项目,分别于治疗前、治疗后48 h及治疗后7天对血肌酐浓度、血尿素氮、血清胱抑素C等指标进行检测,并计算肌酐清除率。结果:治疗48h,相对于治疗前,观察组在以上除BUN等方面均明显改善;对照组在以上除BUN和Cys C等方面均明显改善;且观察组患者的Cys C明显低于对照组。治疗7天,相比于治疗前,观察组患者在以上相同指标等方面显著改善;对照组患者在以上除BUN等方面显著改善;且观察组患者的以上除每小时尿量和MAP指标明显改善,差异均有统计学意义(P<0.05)。结论:虽然曲美他嗪不能明显提高抗休克救治的成功率,但对休克患者的肾脏功能具有显著的改善作用;并且,远期治疗效果更佳,可作为休克患者治疗的辅助性用药应用。

Objective： To investigate the improvemment effect of trimetazidine on renal function in patients with shock. Methods：From 2011 April to 2014 March in our hospital treated 160 cases of shock patients,randomly divided into observation group and control group,each group were given anti shock treatment routine,the observation group added trimetazidine hydrochloride oral treatment,control group with placebo treatment.Recording of the patient＆#39;s urine volume per hour and other 6 projects,respectively,before treatment and after treatment 48 h and 7 days after treatment to the patient＆#39;s blood creatinine,blood urea nitrogen,serum cystatin C were detected,and the creatinine clearance rate was calculated.Results：48h after treatment,compared with before treatment,the observation group in aspects such as above except BUN were significantly improved; the control group in the above except BUN and Cys C significantly improved; and the patients in the observation group Cys C was significantly lower than that of control group.7 days after treatment,compared with before treatment,the patients in observation group were significantly improved in the same index above; the control group patients in the above aspects except BUN improved significantly;and the patients in the observation group in addition to the above per hour urine volume and MAP index improved obviously,the difference was statistically significant （P 〈 0.05）.Conclusion：Although trimetazidine did not significantly improve the success rate of anti shock treatment,but the shock patients renal function has a significant improvement; and the better the effect of Long-term treatment,it can be applied as a adjuvant therapy for shock patients.