红霉素和阿奇霉素治疗小儿肺炎支原体肺炎随机对照研究

Randomized Controlled Study of Erythromycin and Azithromycin in Treatment of Children With Mycoplasma Pneumoniae Pneumonia

目的：观察对比红霉素和阿奇霉素对小儿肺炎支原体肺炎的疗效。方法选取本院2014年2月～2015年2月收治的小儿肺炎支原体肺炎患儿150例，随机分为对照组与观察组各75人，所有患儿均给予止咳祛痰、退烧去热对症治疗，观察组给予阿奇霉素治疗，对照组给予红霉素治疗，观察两组患儿的疗效及不良反应。结果观察组的总有效率（92%）高于对照组的总有效率（76%）；观察组不良反应发生率低于对照组，P〈0.05，差异具有统计学意义。结论阿奇霉素对小儿肺炎支原体肺炎的治疗，相比红霉素具有疗效好、不良反应发生率低等优点，目前是治疗小儿肺炎支原体肺炎的一种较佳方案。

Objective To observe the curative effect comparison of erythromycin and azithromycin on mycoplasma pneumoniae pneumonia in children.Methods A total of 150 cases of children with mycoplasma pneumonia in our hospital from 2014 February to February 2015,were randomly divided into control group and observation group of 75 people,al of them were given expectorant cough,fever to heat treatment,the observation group was given azithromycin treatment,the control group was given erythromycin treatment,curative effect and adverse reaction of two groups children were observed. ResultsThe total effective rate in the observation group（92%）was higher than that of the control group in the total efficiency（76%）,the incidence of adverse reactions was significantly lower than the control group,P〈 0.05,the difference was statisticaly significant.Conclusion The treatment of azithromycin on mycoplasma pneumoniae pneumonia in children,compared with erythromycin had good curative effect,adverse reaction rate is low,there is a better solution in the treatment of children with mycoplasma pneumonia.