奥美拉唑与西咪替丁在应激性胃溃疡治疗中的临床探讨

Clinical Study of Omeprazole and Cimetidine in the Treatment of Stress Ulcer

目的探讨奥美拉唑和西咪替丁在应激性胃溃疡(Stress Ulcer,SU)治疗中的应用价值。方法取54例SU患者,随机分为对照组、观察组各27例,前者给予西咪替丁治疗,后者给予奥美拉唑治疗,对比相关指标。结果对照组显效率、治疗后胃液PH值均低于观察组,对照组住院时间、出血持续时间均高于观察组,差异具有统计学意义(P<0.05);两组均未见大出血、药物不良反应。结论相较于西咪替丁,奥美拉唑治疗SU,抑制胃酸分泌效果更好、更迅速,止血效果更快、疗效更好,缩短患者住院时间。

Objective To investigate the value of omeprazole and cimetidine in the treatment of stress-induced gastric ulcer.MethodsTaking SU,54 cases were randomly divided into two groups,each group was observed in 27 cases,the former giving cimetidine therapy,control group was given to omeprazole treatment,comparing relevant indicators.Results The control group efficiency,gastric PH value after treatment lower than in the observation group, the duration of hospitalization in the control group,whilst the duration of bleeding which was higher than in the observation group,the difference was statisticaly significant（P〈 0.05）,since the two groups showed no bleeding or adverse drug reactions.Conclusion Compared with cimetidine, omeprazole SU inhibited gastric acid secretion,better results more quickly,faster homeostasis,better efficacy and reduce hospitalization time.