70例慢性阻塞性肺疾病合并呼吸衰竭的临床分析与治疗

Clinical analysis and treatment of 70 cases of chronic obstructive pulmonary disease complicated with respiratory failure

目的研究慢性阻塞性肺疾病合并呼吸衰竭的临床治疗方法。方法 70例慢性阻塞性肺疾病合并呼吸衰竭患者,随机分为研究组与对照组,每组35例。研究组患者静脉滴注纳洛酮+无创呼吸机辅助呼吸治疗,对照组患者静脉滴注纳洛酮治疗,对比两组呼吸频率(RR)、心率(HR)、动脉血气指标的变化。结果研究组治疗后总有效率明显高于对照组,差异有统计学意义(P<0.05);研究组治疗后RR、HR明显下降,氧分压(Pa O2)明显上升,二氧化碳分压(Pa CO2)明显下降,明显优于对照组,差异有统计学意义(P<0.05)。结论采用纳洛酮与无创呼吸机联合治疗慢性阻塞性肺疾病并发呼吸衰竭可提高治疗效果,改善动脉血气指标,值得推广。

Objective To research the clinical treatment methods of chronic obstructive pulmonary disease complicated with respiratory failure.Methods A total of 70 patients of chronic obstructive pulmonary disease complicated with respiratory failure were randomly divided into research group and control group, and each group contained 35 cases. The research group received naloxone by intravenous drip＋non-invasive ventilator in auxiliary respiratory therapy, and the control group received naloxone by intravenous drip for treatment. Changes of respiratory rate, heart rate, and arterial blood gases index were compared between the two groups.Results The research group had obviously higher total effective rate than the control group, and the difference had statistical significance （P〈0.05）. After treatment, the research group had remarkably lowered RR, HR, partial pressure of carbon dioxide in artery （PaCO2）, and obviously increased partial pressure of oxygen （PaO2）. These were all better than those of the control group, and the differences had statistical significance （P〈0.05）.Conclusion Implement of naloxone and non-invasive ventilator can improve the curative effect in combined treatment of chronic obstructive pulmonary disease complicated with respiratory failure. This method can also improve arterial blood gases index, and it is worthy of promotion.