布地奈德联合病毒唑与可必特交替雾化对婴幼儿毛细支气管炎的疗效分析

Curative effect analysis of budesonide combined with ribavirin and combivent in alternating aerosol for infantile capillary bronchitis

目的比较布地奈德联合病毒唑与可必特交替雾化与布地奈德联合病毒唑或布地奈德联合可必特治疗婴幼儿毛细支气管炎的临床效果。方法 90例毛细支气管炎患儿,随机分为A、B、C三组,每组30例。A组应用布地奈德联合病毒唑与可必特交替雾化治疗,B组应用布地奈德联合病毒唑进行雾化吸入,C组应用布地奈德联合可必特进行雾化吸入。比较三组患儿临床症状消失时间、住院时间以及治疗总有效率。结果 A组患儿的咳嗽、喘憋、哮鸣、肺部啰音消失时间分别为(4.3±0.4)d、(2.1±0.4)d、(2.2±0.4)d、(5.5±0.6)d,均明显少于B、C组。住院时间为(7.2±1.0)d,少于B组的(9.7±1.3)d以及C组的(9.9±1.5)d,比较差异均有统计学意义(P<0.05)。A组患儿的治疗总有效率为96.7%,明显高于B组的76.7%以及C组的73.3%,比较差异有统计学意义(P<0.05)。结论布地奈德联合病毒唑与可必特交替雾化治疗在婴幼儿毛细支气管炎中的应用可有效发挥抗炎作用,恢复气道通气功能,改善患儿咳嗽、肺部啰音及喘憋等临床症状,效果显著,具有较高应用价值。

ObjectiveTo compare the clinical effects of budesonide combined with ribavirin and combivent in alternating aerosol, budesonide combined with ribavirin, and budesonide combined with combivent in the treatment of infantile capillary bronchitis.MethodsA total of 90 children with capillary bronchitis were randomly divided into groups A, B and C, with 30 cases in each group. Group A received alternating aerosol by budesonide combined with ribavirin and combivent for treatment, group B received budesonide combined with ribavirin through aerosol inhalation, and group C received budesonide combined with combivent. Comparisons were made on symptoms disappearance time, hospital stay and total effective rate of the three groups.ResultsThe disappearance times of cough, suffocation, stridor, and rale were respectively （4.3±0.4） d, （2.1±0.4） d, （2.2±0.4） d, （5.5±0.6） d, which were all shorter than those in group B and group C. The group A had hospital stay as （7.2±1.0）d, which was shorter than （9.7±1.3） d of group B and （9.9±1.5） d of group C. The differences had statistical significance （P〈0.05）. The total effective rate in group A was 96.7%, which was much higher than 76.7% of group B and 73.3% of group C, and the difference had statistical significance （P〈0.05）.ConclusionImplement of budesonide combined with ribavirin and combivent in alternating aerosol treatment for infantile capillary bronchitis can provide effectively anti-inflammatory action. This method can rehabilitate ventilatory function and improve clinical symptoms of cough, rale and suffocation with remarkable effect. This method contains high value for application.