妊娠中期血清标记物检测在唐氏综合症产前筛查中的探讨

To investigate the serum marker pregnancy detection in prenatal screening for Down syndrome

目的：研究分析妊娠中期血清标记物在产前筛查唐氏综合症的意义。方法：择取2012.10-2013.10期间在我院应用实践分辨免疫荧光法检测的2468例孕15-20＋6周的孕妇，均进行血清Free-β-HCG、AFP标记物含量检测，并结合孕妇的年龄、孕周时间、单双胎、吸烟史、体质量、是否伴有糖尿病、既往有无异常妊娠史等因素，利用Life Cycle 3.0版系统进行风险评估。结果：本组2468例妊娠妇女中，筛出染色体异常的138例高风险妊娠孕妇，其中34例孕妇进行了羊膜腔穿刺产前检查，诊断为唐氏综合症（Down syndrome，DS）者8例，18-三体综合症者1例，其他胎儿染色体异常者4例。DS 胎儿母体血液内AFP、游离雌三醇含量明显低于正常孕妇；Free-β-HCG 含量明显高于正常孕妇，差异P〈0.05有统计学意义。18-三体胎儿母体血液内AFP、游离雌三醇、Free-β-HCG含量明显低于正常孕妇，差异P〈0.05有统计学意义。结论：妊娠中期血清内标记物检查可作为预测胎儿染色体畸形的重要指标，通过产前诊断及时采取有效措施，可以明显减少胎儿出生缺陷，有助于优生工作的进行。

Objective：To study the analysis of second trimester maternal serum marker for prenatal screening of Down＇s syndrome and the significance. Methods：The selection of 2012.10-2013.10 in our hospital during the application of resolution immunofluorescence assay was used to detect 2468 cases of 15-20＋6 weeks pregnant women were detected serum Free-, P-HCG, AFP markers and content, combined with maternal age, gestational weeks, single twins, smoking history, body mass, whether patients with diabetes, previous factors without abnormal pregnancy history, the use of Life Cycle 3 version of the system risk assessment.Results：The 2468 cases of pregnant women, screening out the abnormal chromosome 138 cases of pregnant women with high risk pregnancy, including 34 cases of pregnant women were amniocentesis antenatal examination, diagnosis of Down syndrome （English referred to as DS） in 8 cases, 1 cases of trisomy 18-syndrome, 4 cases of other fetal chromosomal abnormalities. DS maternal fetal blood AFP, free three female alcohol content was significantly lower than that in normal pregnant women;Free-beta-HCG was significantly higher than that of normal pregnant women, the difference was statistical y significant P〈0.05. Trisomy 18-fetal maternal blood AFP, free three female alcohol, Free-beta-HCG was obviously lower than that of normal pregnant women, the difference was statistical y significant P〈0.05. Conclusions：The second trimester serum marker examination can be used as an important index prediction of fetal chromosomal abnormalities, and take effective measures in a timely manner through the prenatal diagnosis, can significantly reduce the birth defects, to help students work.