先进固体核磁共振揭示苯硼酸-壳聚糖纳米粒子非均匀结构和相容性（英文）

Heterogeneous Structure and Miscibility of Phenylboronic Acid-Rich Chitosan Nanoparticles as Revealed by Advanced Solid-State NMR

该文采用先进的固体核磁共振技术研究了壳聚糖-聚3-丙烯酰胺基苯硼酸纳米粒子非均匀结构和高分子间的相容性.13C CPMAS实验表征了壳聚糖与苯硼酸结合后的构象变化,2D 13C-1H HETCOR实验进一步证明了壳聚糖在界面处通过硼酸配位作用与苯硼酸链紧密相连.2D 1H-1H自旋交换和扩散实验阐明了壳聚糖和聚苯硼酸的界面混合性,相分离尺度大约为15-20 nm.

By using advanced solid-state NMR techniques, the heterogeneous structure and inter-polymer miscibility of chitosan-poly （N-3-acrylamidophenyl-boronic acid） nanoparticles （CS-PAPBA NPs） were investigated. The13C CPMAS experiments indicate the conformational change of chitosan when incorporated with phenyl boronic acid. Two-dimensional （2D）13C-1H HETCOR experiments further demonstrate that a portion of chitosan is closely bound with PAPBA in the interphase by means of boronic coordination interaction. 2D1H-1H spin-exchange with spin-diffusion experiments demonstrate that the interfacial mixing of chitosan and PAPBA, and micro-phase separation is of the order of 15–20 nanometers.