首发抑郁障碍患者血清S100B蛋白水平的Meta分析

A meta-analysis of serum S100B level in first-episode depression patients

目的探讨首发抑郁障碍患者与健康者血清S100B蛋白水平的差异,为预防抑郁障碍提供依据。方法计算机检索Pub Med、EMbase、Cochrane Library、万方数据库、CNKI、维普中文期刊数据库以及中国学位论文全文数据库中关于抑郁障碍患者血清S100B蛋白水平的病例对照研究,应用分析软件Rev Man 5.1对血清S100B蛋白水平进行Meta分析。结果共有12篇文献符合纳入标准。Meta分析两组血清S100B蛋白水平的均数差SMD为1.22(95%CI:0.75,1.70),研究组血清S100B蛋白水平高于对照组(Z=5.01,P=0.000)。结论抑郁障碍患者的血清S100B蛋白水平高于健康者。

To investigate the differences in serum SI00B levels between depression patients and healthy people so as to provide additional information for prevention of the first-episode depression. [Methods] Computer retrieval was performed for serum S100B levels in depression patients and healthy peo- ple in PubMed, EMbase, Cochrane Library, Wanfang Data, CNKI, Weipu Data and China Dissertation Database. Meta analyses were conducted about serum S100B levels in the two groups with RevMan 5.1 soft- ware. [Results] Twelve studies met the inclusion criteria. The standardized mean difference （SMD） in serum S100B levels between the depression groups and the healthy groups was 1.22 （95%CI： 0.75, 1.70）. Serum S100B level in the depression groups was higher than that in the healthy control groups （Z= 5.01,P= 0.000）. [Conclusion] Serum SIOOB level in depression patients is higher than that in healthy people.