抑郁症患者的服药依从性及影响因素

Antidepressants Adherence and Its Contributing Factors for Patients with Depression

服药依从性是影响抑郁症患者疗效和复发的重要因素,然而很多研究发现抑郁症患者的服药依从性较低。与服药依从性有关的概念有服从性、依从性和遵从性。抑郁症服药依从性的影响因素包括疾病与治疗因素、医生相关因素、患者相关因素及文化与环境因素四个方面,主要从医生和患者两方面进行干预。其评定方法包括主观和客观两种。介绍了研究趋势,未来应发展服药依从性测量工具,加强本土化和社会文化因素的研究,加强共病对抑郁症服药依从性影响的研究,制定个别化的干预措施,并加强心理学在抑郁症服药依从性领域的交叉研究。

Medication adherence is an important factor in treatment effect and relapse of patients with depression, but many studies have found that patients’ adherence to antidepressants is relatively low. Medication adherence is related to the concept of compliance, adherence and concordance. Contributing factors to antidepressants adherence include disease and treatment factors, physician-related factors, patient-related factors, and cultural and environmental factors. The main interventions address both doctors’ and patients’ sides. The assessments include both subjective and objective methods. The main research trends were introduced. Furthermore, we proposed future directions for this field of study： a） developing measures of antidepressants adherence; b） localizing research and focusing on socio-cultural factors; c） increasing research in comorbidity’ influence on antidepressants adherence; d） developing individualized interventions; and e） increasing multidiscipline research between psychology and the field of antidepressants adherence.