常年性变应性鼻炎特异性免疫治疗的临床分析

Clinical Analysis of Perennial Allergic Rhinitis Specific Immunotherapy

目的：对常年性变应性鼻炎特异性免疫治疗的临床疗效进行研究，希望可以为临床治疗提供借鉴。方法对2011－01～2011－12间在我院用特异性免疫治疗方法治疗常年性变应性鼻炎的205例患者进行回顾分析，并将其作为观察组，经过三年治疗后，在2014年对这205例患者进行回访；然后选取同时期用传统抗组胺类药物联合激素治疗的205例常年性变应性鼻炎患者作为对照组，对比两组患者整体疗效的差异，在治疗前后对这两组的患者进行免疫学检查，观察其免疫学功能的改善情况。结果两组患者总有效率都超过85％，说明两组患者的治疗方法均有明显的疗效，但是差异不具有统计学意义（ P＞0．05）；免疫学功能检查显示，在治疗前后观察组有明显的改善，但是对照组这几种功能水平检测则没有明显改善，差异具有统计学意义（ P＜0．05）。结论特异性免疫治疗常年性变应性鼻炎具有良好的临床疗效，且对于免疫功能有明显的改善作用，能够有效预防和治疗常年性变应性鼻炎，因此值得在临床上大力推广。

Objective To study the clinical efficacy of perennial allergic rhinitis specific immune therapy, hoping to provide reference for the clinical treatment of.Methods For 205 cases of 2011-01~2011-12 in our hospital with specific immune therapy for perennial allergic rhinitis patients were retrospectively analyzed, as the observation group, after three years of treatment, pay a return visit to the 205 patients in 2014;205 cases of perennial allergic rhinitis patients and then take the same period with traditional antihistamines drugs com-bined hormone therapy as the control group, the difference in the overall effect of the two groups, Immunology Examination of the two groups of patients before and after treatment, improvement of immunological function of observation period.Results The total efficiency of two groups of patients were more than 85%, shows obvious curative effect of therapy has two groups of patients, but the difference is not obvi-ous, is not statistically significant （P〉0.05）;second, immunological function tests showed.The observation group venous blood IL-2, IL4 and IL5 levels were significantly improved in the control group before and after treatment, but the detection of several functional level was greatly improved, with significant difference （P〈0.05）.Conclusion The specific immune therapy has a good clinical curative effect of perennial allergic rhinitis, and significant improvement for immune function, can be effective in the prevention and treatment of allergic rhinitis, so it is worth popularizing in clinic.