口服补液盐Ⅲ联合锌剂治疗婴幼儿急性水样便腹泻的临床观察

Clinical observation of oral rehydration salts Ⅲ combined with zinc in the treatment of infants with acute watery diarrhea

目的观察口服补液盐Ⅲ联合锌剂治疗婴幼儿急性水样便腹泻的临床疗效。方法将108例婴幼儿急性水样便腹泻患儿随机分为对照组52例(口服补液盐Ⅰ),治疗组56例(口服补液盐Ⅲ、锌剂),两组常规治疗相同,即调整饮食及对症治疗等。治疗后72 h观察两组病例症状、体征改善情况。结果总有效率治疗组为92.8%,对照组为71.1%,治疗组在发热、呕吐、腹泻缓解时间及总病程等均短于对照组,差异有统计学意义(P<0.05)。结论口服补液盐Ⅲ联合补锌治疗婴幼儿急性水样腹泻,疗效显著可靠,值得临床推广应用。

[Objective]To evaluate the clinical efficacy of oral rehydration salts Ⅲ and zinc in the treatment of infant acute watery diarrhea.[Methods]All of 108 children with acute watery diarrhea were randomly divided into control group（52 cases, treated with ORS Ⅰ） and treatment group（56 cases, treated with ORS Ⅲ and zinc）, Conventional treatment of two groups is the same, that is, adjust the diet and symptomatic treatment, etc. The time of therapy was 3 days. The difference of improvement of symptoms and physical signs were observed in both of groups. [Results]The total effective rate were 92.8% in the treatment group and 71.1% in the control group. The periods of the remission and disappearance of the major symptoms and physical signs were significantly shorter in the treatment group than those in the control group（P〈0.05） including fever,vomit, diarrhea, and the course of diarrhea.[Conclusion]The combinative treatment of oral rehydration salts Ⅲ and zinc is effective in acute watery diarrhea of infant and it is reliable and convenient and should be promoted and applied.