衣原体属及支原体属阳性与宫颈糜烂相关性研究

Correlation of Chlamydiaand Mycoplasma infections with cervical erosion

目的探讨衣原体属及支原体属阳性与宫颈糜烂存在的相关性,并研究不同程度宫颈糜烂患者感染衣原体属及支原体属的阳性率。方法于2012年12月-2013年12月收治的326例宫颈糜烂患者中,在排除假丝酵母菌阴道炎患者后,按照数学随机选取的方法抽取180例患者作为试验组,根据临床症状以及血样检测判断其患病程度,并以此将患者分为重、中、轻度患者3组,选取180名宫颈健康者作为对照组,分别对宫颈糜烂患者及宫颈健康者进行宫颈分泌物采样,并检测其衣原体属、支原体属阳性率,数据采用SPSS12.0软件进行统计分析。结果试验组病原体阳性率70.56%,明显高于对照组的20.00%,差异有统计学意义（P〈0.05）;试验组20-40岁的性活跃期患者病原体阳性率较高,其中30-39岁年龄段病原体阳性率最高为83.56%,〈20岁患者2例,〉50岁患者4例,判定为阳性者分别为2例和1例,但由于样本数量过少,阳性率差异无统计学意义;试验组患者宫颈糜烂程度的不同其病原体阳性率不同,宫颈糜烂程度越深、阳性率越高。结论衣原体属及支原体属阳性与宫颈糜烂关系密切,宫颈糜烂程度的不同其衣原体属及支原体属的阳性率不同,总体表现为宫颈糜烂程度越深,阳性率越高。

OBJECTIVE To investigate correlation of Chlamydia and Mycoplasma infections with cervical erosion and study the positive rate of Chlamydia and Mycoplasma in patients with different degrees of cervical erosion . METHODS Among a total of 326 patients with cervical erosion admitted and treated in Dec .2012 to Dec .2013 , 180 patients were selected as the experimental group by digital random selection method after exclusion of patients with Candida vaginitis .The illness degree of the 180 patients was determined according to the clinical symptoms and blood test and these patients were divided into severe ,moderate and mild groups accordingly .Another 180 patients with healthy cervix were selected as the control group .Samples of cervical secretions were collected from the patients with cervical erosion and the healthy subjects for detection of the positive rate of Chlamydia and Mycoplasma .Data were analyzed by the statistical software SPSS12 .0 .RESULTS The positive rate of pathogens was 70 .56% in the experimental group ,significantly higher than 20 .00% in the control group （P〈0 .05） .The pathogen positive rate was relatively high in the sexually active patients aged 20 -40 years in the experimental group ,with the highest positive rate of 83 .56% in patients aged 30-39 years .There were 2 patients less than 20 years old with positive results and 4 patients older than 50 years old including 1 patient with positive results ,how‐ever ,the difference in the positive rate among these patients was not significant due to the small sample size .The positive rate varied with the erosion degrees among patients in the experimental group ,as the positive rate increased along with the severity of erosion .CONCLUSION There is a close relationship of Chlamydia and Myco‐plasma infections with cervical erosion .The positive rate varied with the erosion degree ,in general ,the positive rate increased along with the severity of erosion .