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血管紧张素转化酶抑制剂与血管紧张素受体拮抗剂临床疗效对比 被引量:7

The comparison of clinical effects between ACEIs and ARBs
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摘要 目前全球范围内,高血压患者超过10亿.高血压是罹患其他心血管系统疾病的重要危险因素.肾素-血管紧张素-醛固酮系统(RAAS)活性增强与高血压密切相关,因此,抑制RAAS是重要的降压手段.在RAAS抑制剂中,血管紧张素转化酶抑制剂(ACEI)及血管紧张素受体拮抗剂(ARB)较为常用.ARB可竞争性抑制血管紧张素Ⅱ(A-Ⅱ)与1型A-Ⅱ(AT1)受体结合,ACEI则通过抑制血管紧张素Ⅰ (A-Ⅰ)转化为A-Ⅱ降低血压.
作者 谢晓川 饶莉
出处 《中国心血管病研究》 CAS 2015年第6期481-484,共4页 Chinese Journal of Cardiovascular Research
基金 国家自然科学基金(项目编号:81270289)
关键词 血管紧张素转化酶抑制剂 血管紧张素受体拮抗剂 Angiotensin-converting enzyme inhibitors(ACEI ) Angiotensin receptor blockers(ARB )
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