胞二磷胆碱联合神经节苷脂治疗新生儿缺氧缺血性脑病神经行为的效果对比

Effect comparison of citicoline combined with ganglioside in the treatment of neurobehavior in neonatal hypoxic ischemic encephalopathy

目的探讨胞二磷胆碱联合神经节苷脂治疗新生儿缺氧缺血性脑病神经行为的效果。方法 40例新生儿缺氧缺血性脑病患儿作为研究对象,随机分为实验组和对照组,每组20例。对照组采用神经节苷脂治疗,实验组在对照组基础上加用胞二磷胆碱治疗,比较两组患儿原始反射、一般状态、新生儿神经行为评分(NBNA)改善情况和临床治疗效果。结果对照组总有效率显著低于实验组,差异有统计学意义(P<0.05)。经过治疗后实验组患儿原始反射、一般状态和NBNA评分均高于对照组,差异有统计学意义(P<0.05)。结论新生儿缺氧缺血性脑病的治疗中,与单用神经节苷脂相比,加用胞二磷胆碱后的治疗效果更佳,对神经行为的改善作用更为显著。

Objective To investigate the effect of citicoline combined with ganglioside in the treatment of neurobehavior in neonatal hypoxic ischemic encephalopathy. Methods A total of 40 children with neonatal hypoxic ischemic encephalopathy as study subjects were randomly divided into experimental group and control group, with 20 cases in each group. The control group received ganglioside for treatment, and the experimental group received additional citicoline. Comparisons were made on primitive reflex, general state, improvement in neonatal behavioral neurological assessment （NBNA）, and clinical effect of the two groups. Results The control group had much lower total effective rate than the experimental group, and the difference had statistical significance （P〈0.05）. After treatment, the experimental group had better primitive reflex, general state, and NBNA score than the control group, and the difference had statistical significance （P〈0.05）. Conclusion Comparing with single ganglioside treatment, combination of citicoline and ganglioside in treating neonatal hypoxic ischemic encephalopathy has better effect and more obvious improvement in neurobehavior.