非那雄胺联合坦索罗辛治疗膀胱过度活动临床疗效分析

Clinical efficacy analysis of finasteride combined tamsulosin against bladder excessive activity

目的:探讨非那雄胺联合坦索罗辛治疗膀胱过度活动的临床疗效。方法:选取某院泌尿外科收治诊断为膀胱过度活动症患者90例,随机分为2组,其中对照组45例,予口服琥珀酸索利那新5 mg·d-1等常规治疗,10 d为1个疗程,治疗2个疗程;实验组45例,予以口服非那雄胺1 mg·d-1,以及坦索罗辛0.2 mg·d-1,10 d为1个疗程,治疗2个疗程。治疗结束后,对比治疗前后患者尿流率参数、排尿日记参数、生活质量评估(QOL)、OABSS评分以及患者治疗总有效率。结果:(1)2组患者治疗前后尿流率参数水平比较:治疗后,2组患者最大尿流率、平均尿流率以及尿量均增加,且实验组(13.92±3.79)ml·s-1、(7.83±4.01)ml·s-1、(270.31±81.53)ml显著优于对照组(12.69±5.21)ml·s-1、(6.03±1.55)ml·s-1、(239.18±74.97)ml,差异有统计学意义(P<0.05);(2)2组患者排尿日记参数比较:治疗后,2组患者排尿次数、尿急次数、急迫性尿失禁次数以及夜尿次数均有所减少,且实验组(9.16±2.24,4.21±2.01,0.65±0.26,1.02±0.85)显著少于对照组(11.45±3.33,6.72±2.24,1.03±0.26,1.78±0.97),差异有统计学意义(P<0.05);(3)2组患者生活质量评估(QOL)比较:治疗后,2组患者生活质量评分均有所上升,且实验组(89分)显著优于对照组(74分),差异有统计学意义(P<0.05);(4)2组患者OABSS评分水平比较:治疗后,2组患者OABSS得分均有所下降,且实验组(2分)下降水平显著优于对照组(6分),差异有统计学意义(P<0.05);(5)2组患者治疗后总有效率比较:治疗后,实验组(89%)总有效率显著高于对照组(78%),差异有统计学意义(P<0.05)。结论:非那雄胺联合坦索罗辛能够明显改善膀胱过度活动症状,对临床具有指导意义,值得临床推广。

OBJECTIVE To investigate the clinical curative effects of finasteride combined tamsulosin for treatment against bladder excessive activity. METHODS A total of 90 patients suffering from bladder excessive activity were randomly divided into two groups. Control group had 45 patients orally administered solid amber acid as conventional treatment at 5 mg·d -1 , 10 days for a treatment course, two courses in total.. Experimental group had 45 patients who were orally administered finasteride 1mg·d-1 and 0. 2 mg·d -1 tansulosin, l0 days as a treatment course, 2 courses in total. Urinary flow rate parameters, voiding diary, quality of life assessment （QOL）, OABSS score and total efficacy were compared between the two groups before and af- ter treatment. RESULTS Comparison of urinary flow rate parameters： maximum urinary flow rate, average urine flow rate and urine volume increased after treatment, more significantly in experimental group （13. 92 ± 3. 79） ml·s-1, （7. 83 ± 4. 01） ml·s -1 , （4. 01±81. 53） ml than in control group （12.69±5.21） ml.s 1,（6.03±1.55） ml-s-1, （1.55±74.97） ml （P 0. 05）. Comparison of voiding diary parameters= numbers of urination,urgency, urge incontinence and night urination decreased after treatment, more significantly in experimental group （9. 16 ± 2. 24, 4. 21 ± 2. 01, 0. 65 ± 0. 26 and 1.02 ± 0. 85） than in control group （11.45 ±3.33, 6. 72 ± 2. 24, 1.03 ±0. 26 and 1.78 ± 0. 97） （P〈0. 05）. Comparison of QOL： QOL was im- proved more significantly in experimental group （89） than in control group （74 points） （P〈0. 05）. Comparison of OABSS score levels= OABSS scores were decreased more significantly in experimental group （2） than in control group （6） （P〈0. 05）. Comparison of total effective rates between the two groups after treatment： the total effective was significantly higher in experi- mental group （89%） than control group （78%） （P〈0. 05）. CONCLUSION Finasteride combined Tamsulosin can obviously improve symptoms of bladder excessive activity, with guiding significance, and worthy to be promoted.