胸腺肽α1结合抗凝与单纯抗凝治疗深静脉血栓形成的对比研究

Comparative Study of Thymosin α1 Combining Anti-coagulation Medication and Simple Anticoagulation Medication for Treating the Patients With Deep Venous Thrombosis Formation

目的 :对比深静脉血栓形成患者予胸腺肽α1结合抗凝与单纯抗凝的疗效。方法 :经下肢静脉彩色超声确诊为深静脉血栓形成的患者92例,采用随机数字表将病例随机分为胸腺肽α1结合抗凝组(45例)、单纯抗凝组(47例)。比较胸腺肽α1结合抗凝组和单纯抗凝组治疗前后深静脉血栓变化。结果 :治疗4周后,胸腺肽α1结合抗凝组(136支)与单纯抗凝组(145支)比较,血栓完全溶解的血管支数分别为67支(49.26%)和54支(37.24%);血栓进展或复发的血管支数分别为6支(4.41%)和16支(11.03%),差异均有统计学意义(P<0.05)。结论 :对深静脉血栓形成患者,胸腺肽α1结合抗凝的疗效优于单纯抗凝。

Objective： To compare the therapeutic effect of thymosin α1 combining anti-coagulation medication and simple anti-coagulation mediation in treating the patients with deep venous thrombosis （DVT） formation. Methods： A total of 92 patients with lower extremity vascular ultrasound conifrmed diagnosis of DVT were studied. The patients were randomly divided into 2 groups for treatment： Combination group, the patients received thymosin α1 combining anti-coagulation medication,n=45 and Simple group, the patients received only anti-coagulation medication,n=47. The changes of their deep venous thrombosis condition after treatment were compared between 2 groups. Results： By 4 weeks treatment, the proportion of completely dissolved thrombus in Combination group and in Simple group were 67 branches （49.26%） and 54 branches （37.24%）; the thrombus progression and recurrence condition were 6 branches （4.41%） and 16 branches （11.03%）, allP〈0.05. Conclusion： Thymosin α1 combining anti-coagulation medication has the better effect than simple anti-coagulation medication for treating DVT patients.